Summary of age-derived aggravations of liver pathologies where Mg2+ has a preventive effect and hypomagnesemia increases risk of development. Abbreviations list: ALD, alcoholic liver disease; ALF, acute liver failure; C/EBP, CCAAT-enhanced-binding proteins; FXR, farnesoid R receptor; HBV, hepatitis B; HCC, hepatocellular carcinoma; HSC, hepatic stellate cell; IR, insulin resistance; KC, Kupffer cells; NASH, NAFLD encompasses a spectrum of diseases ranging from steatosis to steatohepatitis; NAFLD, nonlcoholic fatty liver disease; ROS, reactive oxygen species; RT, reverse telomerase; T2DM, type 2 diabetes mellitus.