Table 2.
Clinical associations with stroke despite anticoagulation.
| Variable | Crude OR (95% CI) | p Value | Model 1 adjusted OR (95% CI) | p Value | Model 2 adjusted OR (95% CI) | p Value |
|---|---|---|---|---|---|---|
| Hypertension | 2.19 (1.40–3.42) | 0.001 | 1.93 (1.22–3.07) | 0.005 | ||
| CCF | 1.53 (1.01–2.31) | 0.05 | 1.50 (0.96–2.33) | 0.07 | ||
| CHA2DS2-VASC (per point) | 1.41 (1.26–1.57) | <0.001 | 1.41 (1.26–1.58) | <0.001 | ||
| Previous stroke/TIA or systemic embolism | 2.84 (1.98–4.07) | <0.001 | 2.90 (2.00–4.20) | <0.001 | ||
| Proximal large artery atheroma ⩾50% | 1.74 (1.08–2.80) | 0.02 | 1.78 (1.07–2.94) | 0.03 | 1.67 (1.02–2.74) | 0.04 |
| Small vessel occlusion | 1.98 (1.00–3.94) | 0.05 | 2.46 (1.20–5.06) | 0.01 | 2.41 (1.18–4.92) | 0.02 |
Odds ratio (OR) and 95% CIs were calculated from logistic regression. The adjusted models were derived from a stepwise backward logistic regression analysis.