Table 3.
High-resolution Manometry Findings Between Chicago Classification Versions 3.0 and 4.0 in Patients With Achalasia
| HRM findings | CC v3.0 (n = 27) | Diagnosis changeda (n = 7) | CC v4.0 (n = 34) | P-value |
|---|---|---|---|---|
| Supine IRP (mmHg) | 39.0 (31.0-47.5)e | 18.3 (14.3-21.1)e,f | 37.0 (21.3-44.8)f | 0.002 |
| Supine DCI (mmHg·s·cm) | 919.0 (224.0-1868.0)e | 198.5 (16.7-334.6)e,f | 615.5 (192.3-1811.8)f | 0.031 |
| Supine DL (sec) | 3.5 (2.2-5.6) | 7.0 (4.9-9.0) | 3.8 (2.4-5.9) | 0.158 |
| Upright IRP (mmHg) | 34.0 (29.0-44.0)e | 15.5 (6.0-19.5)e,f | 32.0 (24.5-40.5)f | 0.002 |
| Upright DCI (mmHg·s·cm) | 240.0 (66.0-1944.0) | 69.0 (6.8-233.8) | 220.0 (52.5-608.0) | 0.248 |
| Upright DL (sec) | 3.5 (2.0-5.5)e | 7.5 (6.4-8.5)e,f | 4.4 (2.4-6.7)c | 0.027 |
| MRS-IRP (mmHg)b | 37.0 (29.0-45.5)e | 18.0 (13.3-19.5)e,f | 33.0 (22.0-42.0)f | 0.001 |
| MRS-DCI (mmHg·s·cm)c | 1039.0 (230.0-2730.0) | 193.5 (24.8-521.5) | 686.0 (221.0-2372.0) | 0.063 |
| RDC-IRP (mmHg)d | 32.0 (26.0-40.0)e,g | 14.0 (7.0-22.0)e,f | 27.5 (22.3-38.5)f,h | 0.001 |
aDiagnosis changed from others (2 absent contractility, 5 ineffective esophageal motility) to achalasia.
bIntegrated relaxation pressure (IRP) during multiple rapid swallows (MRS).
cDistal contractile integral (DCI) during MRS.
dIRP during rapid drink challenge (RDC).
eP < 0.005, compared between CC v3.0 and diagnosis diagnosis-changed changed group.
fP < 0.005, compared between CC v4.0 and diagnosis diagnosis-changed changed group.
gn = 25.
hn = 32.
HRM, high-resolution manometry; DL, distal latency.
Data are presented as median (interquartile range).