Table 1.
Main unit costs (2018–2019) used in cost-effectiveness/utility analysis and sources of information
| Item | Unit cost (£) | Source |
|---|---|---|
| Intervention | ||
| TURBT | ||
| Hexvix | 347.00 | Dindyal et al 2008 [32]a |
| Operating surgeon | ||
| Consultant | 108.00 | Unit costs of health and social care, 2018 [33], VI. Hospital-based health care staff: 14. Hospital-based doctors, Consultant surgical |
| Registrar | 43.00 | Unit costs of health and social care, 2018 [33], VI. Hospital-based health care staff: 14. Hospital-based doctors, Registrar |
| Non-consultant | 105.00 | Unit costs of health and social care, 2018 [33], VI. Hospital-based health care staff: 14. Hospital-based doctors, Associate specialist |
| MMC dose (cost per 40-mg vial) | 135.00 | BNF 76th edition [34], NHS indicative price: Mitomycin 40 mg powder and solvent for intravesical solutions vials (medac UK) |
| MMC deliver in the theatre | ||
| Mito-In system (Laboratorios Inibsa SA, Barcelona, Spain) | 4.33 | £4.00 at 2012, NICE guideline [35]a |
| Surgical consultant time (estimate of 2 min) | 5.06 | £4.67 at 2012, NICE guideline [35]a |
| Secondary care | ||
| WL-guided cystoscopy | 1072.76 | £937 HTA report, 2010 [3], [9]a |
| PDD-guided cystoscopy | 1569.65 | £1371 HTA report, 2010 [3], [9]a |
| Narrow-band imaging | 1120.00 | NICE, Narrow band imaging for Barrett’s oesophagus [36] |
| Flexible cystoscopy (day case) | 467.58 | NHS reference costs 2018–2019 [37], HRG (day case) code LB72 A, Diagnostic flexible cystoscopy, 19 yr and over |
| Flexible cystoscopy (outpatient) | 186.79 | NHS reference costs 2018–2019 [37], HRG (outpatient) code LB72 A, Diagnostic flexible cystoscopy, 19 yr and over |
| Induction BCG drug cost (6 doses) | 429.66 | BNF 76th edition [34], NHS indicative price (hospital only), OncoTICE 12.5 mg powder for reconstitution for instillation vials (Merck Sharp and Dohme Ltd.) |
| Induction BCG delivery cost | 1464.88 | £1324.42 at 2012, NICE guideline [35]a |
| Maintenance BCG drug cost (3 doses, 1 every 6 mo) | 214.83 | £1324.42 at 2012, NICE guideline [35]a |
| Maintenance BCG delivery cost | 732.44 | £662.21 at 2012, NICE guideline [35]a |
| Computed tomography scan | 83.23 | NHS reference costs 2018–2019 [37], HRG (diagnostic imaging) code RD20 A, Computerised tomography scan of one area, without contrast, 19 yr and over |
| Magnetic resonance imaging scan | 136.00 | NHS reference costs 2018–2019 [37], HRG (diagnostic imaging) code RD01 A, Magnetic resonance imaging scan of one area, without contrast, 19 yr and over |
| Neoadjuvant chemotherapy | 1207.30 | £1091.54 at 2012, NICE guideline [35]a |
| Radical cystectomy | 10 416.00 | NHS reference costs 2018–2019 [37], HRG (elective inpatient) code LB39D, Cystectomy with urinary diversion and reconstruction, with CC score 0–2 |
| Blood tests (kidney and PSA tests) | 22.12 | £20 at 2012, NICE guideline [35]a |
| Urethroscopy | 961.73 | NHS reference costs 2018–2019 [37], HRG (day case) code LB55 A, Minor or intermediate, urethra procedures, 19 yr and over |
| Urology consultant | 110.82 | NHS reference costs 2018–2019 [37], code 101 (consultant-led) |
| Radical radiotherapy | 1156.00 | HTA report [3]a |
| A&E visit | 168.00 | NHS reference costs 2018–2019 [37], HRG (total unit cost) service code 180 |
| Day case | 752.00 | NHS reference costs 2018–2019 [37], Day case (unit cost) |
| Inpatient attendance | 468.00 | NHS reference costs 2018–2019 [37], Minor bladder procedures, age 19 yr and over (HRG code LB15E), excess bed-day for elective care |
| Outpatient attendance | 108.00 | NHS reference costs 2018–2019 [37], Urology outpatient attendance (service code 101), TOA |
| Primary care | ||
| GP | ||
| At practice | 33.30 | Unit costs of health and social care, 2018 [33] II. Community-based health care staff: 10.3. General practitioner |
| At home | 139.49 | Unit costs of health and social care, 2009 [38] (£120), home visit lasting 23.4 mina |
| Telephone | 15.10 | Unit costs of health and social care, 2018 [33] II. Community-based health care staff: 10.5. Telephone triage, GP-led and nurse-led |
| Out-of-hours | 72.91 | £68.30, out-of-hours GP services in England, Department of Health and Social Care and NHS England [39]a |
| Nurse | ||
| At hospital | 28.00 | Unit costs of health and social care, 2018 [33] VI. Hospital-based health care staff: 13. Hospital-based nurses, Band 2 |
| At practice | 36.00 | Unit costs of health and social care, 2018 [33] II. Community-based health care staff: 10.2. Nurse (GP practice) |
| At home | 23.25 | Unit costs of health and social care, 2009 [38] (£20)a |
| Telephone | 7.70 | Unit costs of health and social care, 2018 [33] II. Community-based health care staff: 10.5. Telephone triage – GP-led and nurse-led |
| Out-of-hours | 72.91 | Assumed to be the same as for GP out-of-hours |
| Hospital doctor | 43.00 | Unit costs of health and social care, 2018 [33]; VI. Hospital-based health care staff: 14. Hospital-based doctors, Registrar |
| Hospital doctor: telephone | 15.10 | Assumed to be the same as for GP-led phone triage |
| Participant and companion travel | ||
| Cost per mile travelled by car | 0.45 | HMRC travel – mileage and fuel rates and allowances [40] |
| Car parking charges | Various | Participant-reported data |
| Cost of public transport fares (e.g., bus, train, taxi) | Various | Participant-reported data |
| Cost of non-emergency participant transport service (via ambulance) | 47.67 | NHS reference costs 2009–2010 [41] (not included in reference costs since 2011)a |
| Participant and companion time | ||
| Paid work | 12.71 | ONS annual survey of hours and earnings time series of selected estimates, 2020 [42] (all employees: median hourly earnings excluding overtime) |
| Full employment | 14.31 | ONS annual survey of hours and earnings time series of selected estimates, 2020 [42] (full-time employees: mean hourly earnings excluding overtime) |
| Part-time employment | 9.34 | ONS annual survey of hours and earnings time series of selected estimates, 2020 [42] (part-time employees: median hourly earnings excluding overtime) |
| Housework | 11.24 | NHS Pay Review Body twenty-sixth report, 2012 [43]a |
| Child care | 12.71 | ONS annual survey of hours and earnings time series of selected estimates, 2020 [44] (as paid work) |
| Caring for someone | 12.71 | ONS annual survey of hours and earnings time series of selected estimates, 2020 [42] (as paid work) |
| Voluntary work | 12.71 | ONS annual survey of hours and earnings time series of selected estimates, 2020 [42] (as paid work) |
| Student | 5.20 | TAG data book v1.13.1 [44] (value of non–working time: other, 2010 valuesa) |
| Leisure activities | 5.20 | TAG data book v1.13.1 [44] (value of non–working time: other, 2010 valuesa) |
| Retired | 5.20 | TAG data book v1.13.1 [44] (value of non–working time: other, 2010 valuesa) |
| Unemployed | 5.20 | TAG data book v1.13.1 [44] (value of non–working time: other, 2010 valuesa) |
TURBT = transurethral resection of bladder tumour; MMC = mitomycin C; BCG = bacillus Calmette-Guérin; A&E: accident and emergency department; NHS = National Health Service; NICE = National Institute for Health and Care Excellence; PSA = prostate-specific antigen; CC = Charlson comorbidity; HTA = health technology assessment; HRG = health resource group; PSSRU = Personal Social Services Research Unit; BNF = British National Formulary; TOA = total outpatient attendance; GP = general practitioner; HMRC = HM Revenue and Customs; ONS = Office for National Statistics; TAG = transport analysis guidance.
a
Inflated to 2018–2019 prices using the Campbell and Cochrane Economics Methods Group/Evidence for Policy and Practice Information and Coordinating Centre inflation calculator [16].