Table 5.
Trial-based cost-effectiveness analysis results for PDD-TURBT versus WL-TURBT
| Analysis | Adjusted mean (95% CI) |
Incremental mean (95% CI) |
ICER (£/QALY) | Probability that PDD-TURBT is cost effective by WTP threshold (%) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Cost (£) | QALYs | Cost (£) | QALYs | £0 | £20 000 | £30 000 | £50 000 | ||
|
Base case analysis Imputed data analysis: 3 yr, NHS/PSS perspective | |||||||||
| WL-TURBT | 12 005 (10 845–13 166) | 2.094 (2.010–2.178) | WL-TURBT dominates |
||||||
| PDD-TURBT | 12 881 (11 713–14 049) | 2.087 (1.996–2.179) | 876 (−766 to 2518) | −0.007 (−0.133 to 0.119) | PDD-TURBT | 21 | 23 | 26 | 30 |
|
Sensitivity analyses Complete-case analysis: 3 yr, NHS/PSS perspective | |||||||||
| WL-TURBT | 12 265 (10 131–14 399) | 2.146 (2.030–2.261) | 95 606 | ||||||
| PDD-TURBT | 15 089 (12 577–17 602) | 2.168 (2.032–2.305) | 3236 (−1081 to 6554) | 0.034 (−0.146 to 0.213) | 2 | 16 | 26 | 38 | |
| Imputed data analysis: 3 yr, wider economic perspective | |||||||||
| WL-TURBT | 13 249 (11 954–14 545) | 2.098 (2.015–2.182) | WL-TURBT dominates |
||||||
| PDD-TURBT | 14 012 (12 719–15 306) | 2.095 (2.005–2.186) | 763 (−1048 to 2574) | −0.003 (−0.123 to 0.116) | PDD-TURBT | 28 | 27 | 30 | 32 |
| Complete-case analysis: 3 yr, wider economic perspective | |||||||||
| WL-TURBT | 14 147 (11 554–16 740) | 2.146 (2.030–2.261) | |||||||
| PDD-TURBT | 16 583 (13 657–19 508) | 2.168 (2.032–2.305) | 2715 (−1101 to 5630) | 0.035 (−0.145 to 0.214) | 78 682 | 2 | 15 | 25 | 38 |
| Imputed data analysis: 3 yr, 0% discount rate | |||||||||
| WL-TURBT | 12 165 (10 975–13 356) | 2.169 (2.083–2.255) | WL-TURBT dominates |
||||||
| PDD-TURBT | 13 055 (11 843–14 266) | 2.168 (2.072–2.264) | 889 (−787 to 2566) | −0.001 (−0.130 to 0.127) | PDD-TURBT | 21 | 26 | 29 | 33 |
| Imputed data analysis: 3 yr, 6% discount rate | |||||||||
| WL-TURBT | 11 879 (10 739–13 019) | 2.047 (1.969–2.126) | WL-TURBT dominates |
||||||
| PDD-TURBT | 12 745 (11 603–13 887) | 2.044 (1.958–2.131) | 886 (−733 to 2465) | −0.003 (−0.119 to 0.113) | PDD-TURBT | 20 | 24 | 27 | 31 |
TURBT = transurethral resection of bladder tumour; PDD-TURBT = photodynamic diagnosis–guided TURBT; WL-TURBT = white light–guided TURBT; CI = confidence interval; ICER = incremental cost-effectiveness ratio; QALY = quality-adjusted life year; NFS = National Health Service; PSS = personal social services; WTP = willingness to pay for 1 additional QALY.