Fig. 3.

Intra-tumoral accumulation of C-LPs and Rg3-LPs in 3D MCF-7/T cell tumor spheroids in vitro. (A) Fluorescence analysis with DiD by confocal microscopy. Fluorescence intensity is a function of the accumulation of C-LPs and Rg3-LPs. A higher fluorescence intensity was observed for Rg3-LPs than C-LPs. Scale bar, 200 μm. (B) Quantitative analysis of the penetration depth of C-LPs and Rg3-LPs in MCF-7/T spheroids. The panel shows confocal z-axis, continuous top-down scanning layers that are 5 mm for each depth level. Data are mean ± SD, n = 3, *p < 0.05, **p < 0.01, ***p < 0.001.