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Confocal laser scanning microscopy showing distribution of Nile Red in Labrafac Lipophile WL1349 (A) or Nile Red-loaded nanocapsules (B) in pig ear skin after a 5-h-long incubation. Distribution of the encapsulated fluorescent dye only in the stratum corneum layer proves inability of nanocapsules to penetrate deeper intracellular skin spaces. Scale bar represents 100 μm.
