Table 2. . Antifungal activity of free ebselen and ebselen-loaded in core-shell nanocapsules against Candida species.
| Candida species | MIC (μg/ml) | |
|---|---|---|
| Free ebselen | Ebselen in Eb-NCS 3 | |
| Candida tropicalis | 1.520 | 0.375 |
| Candida albicans | 0.190 | 0.094 |
| Candida glabrata | 0.024 | 0.094 |
| Candida parapsilosis | 0.015 | 0.012 |
No growth inhibition of any Candida species was observed for Ebselen-free nanocapsules.
Eb-NC: Ebselen-loaded core-shell nanocapsule; MIC: Minimal inhibitory concentration (the lowest concetration of the tested antifungals that inhibited the visible growth of Candida cells after overnight incubation).