Skip to main content
. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Nat Med. 2023 Feb 27;29(3):710–718. doi: 10.1038/s41591-023-02223-9

Extended Display Figure 6. Impact of 1,5 Anhydroglucitol (AHG) on platelet aggregation and calcium release.

Extended Display Figure 6.

Panel A ADP-stimulated and Thrombin receptor-activating peptide (TRAP)6-stimulated platelet aggregometry responses in human platelet-rich plasma incubated with 1,5-AHG (green) versus vehicle (saline, blue). Two-sided P values were calculated by Mann Whitney Test. For ADP and TRAP6 stimulated platelet-rich plasma n=7. Panel B shows thrombin-induced (0.02 U) changes in intracellular calcium concentration in Fura 2-filled washed human platelets incubated with 1,5-AHG (green) or vehicle (saline, blue). Data represent mean (±SD). Two-sided P values were calculated by Wilcoxon matched-pairs signed rank test. Numbers of independent biological replicates (n) are indicated.