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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Nat Med. 2023 Feb 27;29(3):710–718. doi: 10.1038/s41591-023-02223-9

Extended Display Figure 4. Erythritol increases platelet aggregation responses to submaximal concentrations of agonists.

Extended Display Figure 4.

ADP-stimulated and Thrombin receptor-activating peptide(TRAP)6-stimulated platelet aggregometry responses of human platelet-rich plasma with fixed concentration of erythritol (45 or 90 μM, red) versus normal saline (vehicle, blue). Data in bar graphs are represented as means (±SD), and two-sided P values were calculated by Mann Whitney Test (bar graphs) and by 2-way analysis of variance (overall P value is shown for erythritol effect) with Sidák’s post hoc test. Sidák’s adjusted P values for Erythritol 45 μM vs. vehicle: for ADP 2 μM P=0.01, ADP 3 μM P=0.005, for erythritol 90 μM vs. vehicle: TRAP6 5 μM: P=0.0002. Numbers of independent biological replicates (n) are indicated. *P<0.05, ** P<0.01, ***P<0.001.