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. 2023 Apr 26;13(6):673–682. doi: 10.1016/j.jpha.2023.04.015

Fig. 3.

Fig. 3

Testing of compatibility between cell membrane-based glucose sensor (CMGS) and glucose transporter 1 (GLUT1) down-regulated membranes. (A) The mechanism of small interfering RNA (siRNA) and small drug molecules interfering GLUT1 expression. (B) siRNA1 knockdown GLUT1 expression (insert figure) in H1299 cells and current response of CMGS to glucose. (C) siRNA3 knockdown GLUT1 expression (insert figure) in MGC803 cells and current response of CMGS to glucose. (D) Apigenin down-regulated GLUT1 expression (insert figure) in H1299 cells and current response of CMGS to glucose. (E) Phloretin down-regulated GLUT1 expression (insert figure) in MGC803 cells and current response of CMGS to glucose. (F) Current difference between siRNA, drug molecules down-regulated group, and untreated group. ∗P < 0.05; ∗∗P < 0.01; and ∗∗∗P < 0.001. NC: negative control.