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. 2023 Apr 26;13(6):673–682. doi: 10.1016/j.jpha.2023.04.015

Fig. 5.

Fig. 5

Screening test of cell membrane-based glucose sensor (CMGS) towards active components in catechins. (A) Current response ratios of CMGS treated with different concentrations of epigallocatechin gallate (EGCG). (B) Current responses of CMGS and corresponding 2-deoxyglucose (2-DG) uptake ratios after EGCG treatment at different concentrations (blue histogram: the uptake rates of different concentration EGCG-treated H1299 cells; red histogram: the current response of CMGS treated with different concentration EGCG). (C) Current responses of CMGS coated with different cell membranes treated with EGCG. (D) Current response curves of CMGS treated with different catechin monomers. (E) Current responses of CMGS treated with catechin monomers and the corresponding 2-DG uptake ratios (blue histogram: the uptake rates of dcatechin monomers treated H1299 cells; red histogram: the current response of CMGS treated with catechin monomers). (F) Cluster analysis and (G) principal component analysis of CMGS current responses and 2-DG uptake ratios treated with catechin monomers. (H) The survival rate of H1299 cells treated with different catechin monomers. ∗∗P < 0.01 and ∗∗∗P < 0.001, compared with the control group. EC: epicatechin; ECG: epicatechin gallate; GC: gallocatechin; EGC: epigallocatechin.