Table 1. Baseline Characteristics of Patients With Large Vessel Occlusion.
| No. (%) | P value | ||
|---|---|---|---|
| IV tenecteplase (n = 263) | IV alteplase (n = 257) | ||
| Baseline characteristics | |||
| Age, median (IQR), y | 74 (65-84) | 73 (63-83) | .38 |
| Female | 143 (54.4) | 140 (54.5) | .99 |
| Male | 120 (46.6) | 117 (46.5) | |
| Baseline NIHSS score, median (IQR) | 17 (11-22) | 17 (12-22) | .60 |
| Workflow times, min | |||
| Onset to hospital arrival (n = 518) | 72 (47-115) | 75 (52-129) | .29 |
| Onset to needle (n = 515) | 106 (84-150) | 111 (86-177) | .18 |
| Imaging to arterial access (in patients undergoing EVT [n = 408]) | 57 (40-84) | 55 (40-79) | .42 |
| Arterial access to successful reperfusion (in patients undergoing EVT [n = 345]) | 35 (22-57) | 33.5 (20-49) | .10 |
| Needle to reperfusion assessment (in patients undergoing EVT [n = 473]) | 57 (39-83) | 52 (35-77) | .17 |
| Needle to first successful reperfusion (in patients undergoing EVT [n = 342]) | 80.5 (57-114) | 75.5 (53.5-103.5) | .23 |
| Type of enrolling center | |||
| Primary stroke | 15 (5.7) | 15 (5.8) | .99 |
| Comprehensive stroke | 248 (94.3) | 242 (94.2) | |
| EVT utilization | 207 (78.7) | 201 (78.2) | .92 |
| Imaging characteristics | |||
| Occlusion location | |||
| ICA | 69 (26.2) | 66 (25.7) | .26 |
| M1-MCA | 118 (44.9) | 119 (46.3) | |
| M2-MCA | 65 (24.7) | 52 (20.2) | |
| Basilar artery | 11 (4.2) | 20 (7.8) | |
| Carotid tandem lesion (n = 517) | 61 (23.5) | 47 (18.3) | .16 |
| Collateral grade (anterior circulation occlusions [n = 486]), No. | 251 | 235 | .54 |
| Poor | 32 (12.7) | 31 (13.2) | |
| Intermediate | 142 (56.6) | 122 (51.9) | |
| Good | 77 (30.7) | 82 (34.9) | |
| ASPECTS, median (IQR) | 8 (7-10) | 8 (7-10) | .43 |
Abbreviations: ASPECTS, Alberta Stroke Program Early Computed Tomography Score; EVT, endovascular thrombectomy; ICA, intracranial internal carotid artery; IV, intravenous; M1-MCA, first segment of the middle cerebral artery; M2-MCA, second segment of the middle cerebral artery; NIHSS, National Institutes of Health Stroke Scale.