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. 2023 Jun 30;35(3):283–298. doi: 10.21147/j.issn.1000-9604.2023.03.07

Table 1. Ongoing clinical trials involving anti-NKG2A alone or in combination with other therapies.

Trial identifier Phase Participants Drugs Condition or diseases Status
PD-(L)1, programmed cell death 1/programmed cell death 1 ligand.
NCT04307329 Phase 2 38 Monalizumab, trastuzumab Breast cancer Active, not recruiting
NCT04590963 Phase 3 369 Monalizumab, cetuximab Squamous cell carcinoma of the head and neck Active, not recruiting
NCT05221840 Phase 3 999 Durvalumab with monalizumab or oleclumab Non-small cell lung cancer Recruiting
NCT05414032 Phase 2 200 Monalizumab, cetuximab Locoregionally advanced head and neck squamous cell carcinoma Not yet recruiting
NCT02643550 Phase 1,
Phase 2
143 Monalizumab and cetuximab with or without anti-PD-(L)1 Head and neck neoplasms Active, not recruiting
NCT03822351 Phase 2 188 Durvalumab alone or with monalizumab or oleclumab Stage III non-small cell lung cancer, unresectable Active, not recruiting
NCT05061550 Phase 2 210 Durvalumab with oleclumab or monalizumab Non-small cell lung cancer Recruiting
NCT03088059 Phase 2 340 Monalizumab alone or with durvalumab and other interventions Carcinoma, squamous cell of head and neck Recruiting
NCT03833440 Phase 2 120 Durvalumab with monalizumab or oleclumab or other interventions Non-small cell lung cancer Recruiting