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. 2023 Jun 30;35(3):197–232. doi: 10.21147/j.issn.1000-9604.2023.03.01

Table 11. Adjuvant chemoradiotherapy stratification treatment recommendations for stage II−III rectal cancer.

Risk stratification for recurrence of stage II−III rectal cancer Treatments Recommended level
TME, total mesorectal excision; CRM, circumferential resection margin; MRF, mesorectal fascia.
Meeting any of the following criteria:
 T3−4N0 low;
 CRM+;
 pN+;
 Tumor deposits (TDs)
 Nerve invasion + poor quality of TME operation/mesenteric
 defects/the quality of TME operation could not be evaluated
Postoperative concurrent chemoradiotherapy Recommended
Meeting all the following criteria:
 T3−4aN0 if middle or high;
 CRM−;
 pN0;
Postoperative concurrent chemoradiotherapy Not suggested
 Nerve invasion−;
 Good quality of TME operation/smooth and intact mesentery