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. 2023 Jul 11;23:148. doi: 10.1186/s12902-023-01407-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The effects of IL4I1 on cell proliferation and metastasis in vitro. A 8505C cell (ATC) had the highest IL4I1 expression in the thyroid cancer cell lines K1, KTC-1, TPC-1 and 8505C tested by qPCR (** p < 0.01). B 8505C cell with IL4I1 knocked down by lentivirus containing shRNA targeting IL4I1 (8505C-shIL4I1) had lower IL4I1 expression compared with its control (8505C-vector) (** p < 0.01). C 8505C-shIL4I1 cell had lower IL4I1 protein level compared with 8505C-vector (cropping blots). D The cell proliferation assay showed the impaired proliferation without IL4I1 (*** p < 0.001). E The migration and invasion ability of 8505C-shIL4I1 cell was significantly weaken (** p < 0.01)