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. Author manuscript; available in PMC: 2024 May 16.
Published in final edited form as: Vaccine. 2023 Apr 24;41(21):3367–3379. doi: 10.1016/j.vaccine.2023.04.042

Table 3:

Monoclonal antibody characterization.

Isotype Gamete Immunoblot Gamete surface reactivityb Immuno-precipitation
TRAa ID Full name Heavy & Light Chain Non-reduce d Reduced WT 230 minus
1 2C7 F5 04F5.2C7 IgG2a, Kappa 25 neg pos pos
2 1H1 F3 09B9.1H1 IgG2a, Kappa 25 neg pos pos
3 1G9 F2 14E5.1G9 IgG1, Kappa 48 neg pos pos
4 7E5 F5 06D11.7E5 IgG2a, Kappa 230 neg pos neg
5 5E1 F3 09F4.5E1 IgG1, Kappa 230 neg pos neg
6 2F5 F3 05A6.2F5 IgG2a, Kappa 230 neg pos neg
7 2H11 F3 14A1.2H11 IgG2b, Kappa neg neg pos neg 230
8 11A6 F6 30C5.11A6 IgG2a, Kappa neg neg pos pos 230 & 47
nonTRA
1 8F5 F6 13C10.8F5 IgG2a, Kappa 48 neg pos pos
2 2D8 F4 05H5.2D8 IgG2a, Kappa 80–100 neg pos ND HSP90+
3 4D2 F3 14D10.4D2 IgG1, Kappa 230 neg pos neg
4 5E2 F3 08F1.5E2 IgG1, Kappa 230 neg pos neg
5 7B6 F3 08D6.7B6 IgG2a, Kappa 230 >230 pos neg
6 5B9 F3 05H1.5B9 IgG2a, Kappa neg neg pos neg
7 8G6 F3 04C6.8G6 IgG2b, Kappa neg neg pos neg
8 3F10 F5 09G9.3F10 IgG1, Kappa neg neg pos neg
9 2F8 F3 06D6.2F8 IgG1, Kappa neg neg pos neg
10 1B1 F4 11D9.1B1 IgG1, Kappa neg neg pos neg
11 6C6 F2 18F12.6C6 IgG2a, Kappa neg neg pos pos
Control
12 1A12 F2 03G2.1A12 IgG1, Kappa neg neg neg ND
a

Characteristics of the 8 transmission-reducing (TRA), 11 non-transmission-reducing (nonTRA), and 1 control monoclonal are listed.

b

Wild-type (WT) and Pfs230Δ452–3135 gametes/zygotes (230 minus) were used to detect surface reactivity.