Table 1.
Baseline characteristics
| Variables | Unmatched | Matched | ||||||
|---|---|---|---|---|---|---|---|---|
| Total | Standard treatment | ARNI | P value | Total | Standard treatment | ARNI | P value | |
| Number of patients | 2096 | 1826 | 270 | 778 | 525 | 253 | ||
| Age (years), median (IQR) | 71.0 (64.0–77.0) | 72.0 (64.0–78.0) | 67.0 (56.0-75.3) | < 0.001 | 68.0 (58.0–76.0) | 69.0 (60.0–76.0) | 68.0 (57.0–76.0) | 0.313 |
| Gender, n (%) | < 0.001 | 0.887 | ||||||
| Male | 1241 (59.2) | 1043 (57.1) | 198 (73.3) | 554 (71.2) | 373 (71.0) | 181 (71.5) | ||
| Female | 855 (40.8) | 783 (42.9) | 72 (26.7) | 224 (28.8) | 152 (29.0) | 72 (28.5) | ||
| Height (cm), median (IQR) | 160.0 (155.0-166.0) | 160.0 (155.0-165.0) | 163.0 (158.0-169.0) | < 0.001 | 163.0 (158.0-168.0) | 163.6 (158.0-168.0) | 163.0 (158.0-168.5) | 0.854 |
| Weight (kg), median (IQR) | 60.0 (53.7–68.0) | 60.0 (53.0–67.0) | 61.3 (55.0–70.0) | 0.013 | 62.2 (55.0–70.0) | 63.0 (55.0–70.0) | 60.0 (54.5–70.0) | 0.167 |
| BMI (kg/m2), median (IQR) | 23.4 (21.2–25.4) | 23.4 (21.2–25.4) | 23.4 (21.0-25.8) | 0.791 | 23.5 (21.3–25.8) | 23.7 (21.4–25.9) | 23.3 (20.9–25.7) | 0.168 |
| Smoking, n (%) | 728 (34.7) | 594 (32.5) | 134 (49.6) | < 0.001 | 352 (45.2) | 230 (43.8) | 122 (48.2) | 0.247 |
| Drinking, n (%) | 556 (26.5) | 450 (24.6) | 106 (39.3) | < 0.001 | 282 (36.2) | 185 (35.2) | 97 (38.3) | 0.399 |
| Medical history, n (%) | ||||||||
| MI | 20 (1.0) | 16 (0.9) | 4 (1.5) | 0.314 | 10 (1.3) | 6 (1.1) | 4 (1.6) | 0.611 |
| Angina | 7 (0.3) | 7 (0.4) | 0 (0.0) | 0.605 | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| HF | 1 (0.0) | 1 (0.1) | 0 (0.0) | 1.000 | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Ischemic stroke | 169 (8.1) | 152 (8.3) | 17 (6.3) | 0.253 | 66 (8.5) | 51 (9.7) | 15 (5.9) | 0.098 |
| Arrhythmia | 20 (1.0) | 18 (1.0) | 2 (0.7) | 1.000 | 5 (0.6) | 3 (0.6) | 2 (0.8) | 0.720 |
| PAD | 1471 (70.2) | 1248 (68.3) | 223 (82.6) | < 0.001 | 605 (77.8) | 399 (76.0) | 206 (81.4) | 0.088 |
| Diabetes | 390 (18.6) | 342 (18.7) | 48 (17.8) | 0.708 | 135 (17.4) | 92 (17.5) | 43 (17.0) | 0.856 |
| Hypertension | 928 (44.3) | 799 (43.8) | 129 (47.8) | 0.214 | 360 (46.3) | 242 (46.1) | 118 (46.6) | 0.886 |
| CKD | 38 (1.8) | 32 (1.8) | 6 (2.2) | 0.622 | 20 (2.6) | 14 (2.7) | 6 (2.4) | 0.807 |
| Renal insufficiency | 17 (0.8) | 15 (0.8) | 2 (0.7) | 1.000 | 8 (1.0) | 6 (1.1) | 2 (0.8) | 1.000 |
| Hyperlipidemia | 20 (1.0) | 16 (0.9) | 4 (1.5) | 0.314 | 7 (0.9) | 3 (0.6) | 4 (1.6) | 0.223 |
| Depression | 6 (0.3) | 6 (0.3) | 0 (0.0) | 1.000 | 0 (0.0) | 0 (0.0) | 0 (0.0) | / |
| Type of HF, n (%) | < 0.001 | 0.296 | ||||||
| HFrEF | 364 (17.4) | 245 (13.4) | 119 (44.1) | 293 (37.7) | 190 (36.2) | 103 (40.7) | ||
| HFmrEF | 315 (15.0) | 256 (14.0) | 59 (21.9) | 172 (22.1) | 114 (21.7) | 58 (22.9) | ||
| HFpEF | 1417 (67.6) | 1325 (72.6) | 92 (34.1) | 313 (40.2) | 221 (42.1) | 92 (36.4) | ||
| NYHA classification, n (%) | < 0.001 | 0.573 | ||||||
| I | 323 (15.4) | 298 (16.3) | 25 (9.3) | 82 (10.5) | 58 (11.0) | 24 (9.5) | ||
| II | 866 (41.3) | 785 (43.0) | 81 (30.0) | 252 (32.4) | 173 (33.0) | 79 (31.2) | ||
| III | 714 (34.1) | 585 (32.0) | 129 (47.8) | 338 (43.4) | 220 (41.9) | 118 (46.6) | ||
| IV | 193 (9.2) | 158 (8.7) | 35 (13.0) | 106 (13.6) | 74 (14.1) | 32 (12.6) | ||
IQR, interquartile range; BMI, body mass index; MI, myocardial infarction; PAD, peripheral arterial disease; CKD, chronic kidney disease; HF, heart failure; NYHA, New York Heart Association