Table 1.
Main characteristics and evidence quality of diagnostic meta-analyses
| References | Country | No. of Studies | Quality Assessment | Measurement Parameters | AUC | Outcome | Downgrade Factors | Certainty of the evidence | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | ||||||||
| Zhang,2010 | China | 6 | QUADAS & STARD | sPAP/RVSP | 0.82 |
SE, 0.82 SP, 0.68 |
0 0 |
-2b -2b |
0 0 |
-1e -1e |
0 0 |
very low very low |
| Janda,2011 | Canada | 29 g | QUADAS | RVSP | 0.86 |
SE, 0.83 SP, 0.72 Rh, 0.70 |
-1a -1a -1a |
-1c -1c -2b |
0 0 0 |
-1e -1e -1e |
0 0 -1f |
very low very low very low |
| Taleb,2013 | America | 9 | NR | sPAP | NR |
SE, 0.88 SP, 0.63 |
-1a -1a |
0 -1d |
0 0 |
0 0 |
0 0 |
moderate low |
| Wang,2018 | China | 21 | QUADAS | RVOT AT | 0.90 |
SE, 0.84 SP, 0.84 |
0 0 |
-1c -1d |
0 0 |
0 0 |
0 0 |
moderate moderate |
| Ni,2019 | China | 27 | QUADAS-2 | sPAP/TRPG | 0.88 |
SE, 0.85 SP, 0.74 |
0 0 |
-1c -1c |
0 0 |
-1e -1e |
0 0 |
low low |
| Ullah,2020 | America | 27 | QUADAS-2 | sPAP | NR |
SE, 0.85 SP, 0.71 |
-1a -1a |
-1c -1c |
0 0 |
0 0 |
-1f -1f |
very low very low |
| Tsujimoto,2022 | Japan | 17 | QUADAS-2 | RAP | NR |
SE, 0.87 SP, 0.86 |
-1a -1a |
-1c -1c |
0 0 |
0 0 |
0 0 |
low low |
| Korbitz,2020 | America | 13 | QUADAS-2 | sPAP | 0.81 |
SE, 0.86 SP, 0.87 |
0 0 |
0 -2b |
0 0 |
0 0 |
0 0 |
high low |
| Yin,2020 | China | 11 | QUADAS-2 | sPAP | 0.91 |
SE, 0.85 SP, 0.83 |
0 0 |
-1 -2b |
0 0 |
0 0 |
0 0 |
moderate low |
sPAP systolic pulmonary arterial pressure, RVSP right ventricular systolic pressure, RVOT AT right ventricular outflow tract acceleration time, TRPG tricuspid regurgitation pressure gradient, RAP right atrial pressure, NR not reported, AUC area under the curve, SE sensitivity, SP specificity, QUADAS quality assessment of diagnostic studies tool
aquality assessment suggested risk of bias
bhigh heterogeneity (I2 > 75%)
chigh heterogeneity (I2 > 75%), but heterogeneity was mainly explained
dexistence of heterogeneity (50% < I2 ≤ 75%); e.PH diagnosed by different methods or threshold
fasymmetry on funnel plot
gOf the 29 studies, 27 studies performed meta-analysis of correlation coefficients and 12 studies performed meta-analysis of diagnostic accuracy
hcorrelation coefficients between RVSP and right heart catheterization-derived sPAP