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Rhein inactivates MAPK signaling and activates Nrf2 signaling. (A-E). Western blotting for evaluating the levels of Nrf2 and MAPK signaling-associated proteins in murine gastric mucosa. *P < .05, **P < .01, ***P < .001. MAPK, mitogen-activated protein kinase; Nrf2, erythroid 2-like bZIP transcription factor 2.
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