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. 2023 May 5;46(7):zsad131. doi: 10.1093/sleep/zsad131

Figure 4.

Figure 4.

Dopamine release in the NAc of adolescent R1117X mice during state transitions. (A–D) DA2m traces during the transitions indicated were averaged from all trials (58–195 trials each). 0 seconds indicates time of transition. Shaded area indicates s.e.m. (E–H) Comparison of mean DA2m signal during 5 seconds pre- and post-transition. Paired dots represent data from the same animal (n = 7 mice in WT; 8 mice in R1117X+/+, all trials averaged). Paired t-tests, (E) WT, t = 4.05, df = 6, ** p = 0.007; R1117X+/+, t = 4.42, df = 7, ** p = 0.003, (F) WT, t = 1.91, df = 6, p = 0.11; R1117X+/+, t = 0.36, df = 7, p = 0.73, (G) WT, t = 1.33, df = 6, p = 0.23; R1117X+/+, t = 3.33, df = 7, * p = 0.01, (H) WT, t = 2.87, df = 6, * p = 0.03; R1117X+/+, t = 1.47, df = 7, p = 0.18. (I) Changes in DA2m signal (∆Z-score) between pre- and post-transition stage. n = 7 mice in WT; 8 mice in R1117X+/+. NR, NREM; R, REM; W, wake. Welch’s t-tests within each category, NR to R, t = 0.64, df = 12.97, p = 0.54; NR to W, t = 1.69, df = 12.24, p = 0.12; R to W, t = 2.52, df = 9.51, * p = 0.03; W to NR, t = 3.22, df = 8.38, * p = 0.01. Data are shown as mean ± s.e.m. All tests were two-sided.