Fig. 7.

A model describing the role of MED10b/MED7 in the middle module of Mediator complex as corepressors of JA defense signaling. Knockout MED10b or MED7 derepresses the corepressor activity of the middle module on JA defense gene expression. Upon recognition of pathogen effectors, the CC containing NLRs switch from an inactive state into an activate state and the CC domain of the activated NLRs binds to MED10b. This binding interferes with MED10b and MED7 association and derepresses the MED7–MED10b–JAZ-mediated repression on JA-dependent gene transcription, thus leading to the activation of plant immunity to different pathogens.