Table 1.
Up- and down-regulated microRNAs in fibroblast-derived EVs from patients with HD.
| upregulated | downregulated | |||||
|---|---|---|---|---|---|---|
| miRNA | FC | FDR q value | miRNA | FC | FDR q value | |
| pHD/CTR | hsa-miR-576-3p* | 6,34 | 0,74 | hsa-miR-1260a | -5,95 | 0,75 |
| hsa-miR-184 | 6,25 | 0,75 | hsa-miR-19a-3p | -4,61 | 0,59 | |
| hsa-miR-99a-3p | 4,40 | 0,76 | hsa-miR-30d-3p$ | -3,90 | 0,73 | |
| hsa-miR-34c-3p* | 4,14 | 0,74 | hsa-miR-590-3p | -2,95 | 0,74 | |
| hsa-miR-210-3p | 3,82 | 0,76 | hsa-miR-26b-3p | -2,79 | 0,74 | |
| hsa-miR-1277-3p* | 3,70 | 0,76 | hsa-miR-2355-3p | -2,56 | 0,74 | |
| hsa-miR-377-3p | 3,67 | 0,76 | hsa-miR-18a-3p | -2,49 | 0,74 | |
| hsa-miR-195-3p* | 3,66 | 0,71 | hsa-miR-598-3p | -2,44 | 0,74 | |
| hsa-miR-1228-3p | 3,54 | 0,74 | hsa-miR-2110 | -2,24 | 0,74 | |
| hsa-miR-129-2-3p | 3,51 | 0,74 | hsa-miR-6529-3p | -2,17 | 0,74 | |
| hsa-miR-4454* | 3,46 | 0,74 | hsa-miR-1180-3p | -2,15 | 0,75 | |
| hsa-miR-548l* | 3,40 | 0,76 | hsa-miR-181a-3p | -2,12 | 0,74 | |
| hsa-miR-204-3p | 3,31 | 0,77 | ||||
| hsa-miR-940 | 2,83 | 0,74 | ||||
| hsa-miR-323b-3p* | 2,59 | 0,78 | ||||
| hsa-miR-34a-3p* | 2,41 | 0,78 | ||||
| hsa-miR-5010-3p | 2,29 | 0,78 | ||||
| hsa-miR-324-3p | 2,28 | 0,74 | ||||
| hsa-miR-3158-3p | 2,27 | 0,78 | ||||
| hsa-miR-10401-3p | 2,25 | 0,74 | ||||
| hsa-miR-1843 | 2,21 | 0,74 | ||||
| hsa-miR-1185-2-3p | 2,21 | 0,78 | ||||
| hsa-miR-365a-3p* | 2,18 | 0,74 | ||||
| hsa-miR-365b-3p* | 2,18 | 0,74 | ||||
| hsa-let-7e-3p | 2,13 | 0,74 | ||||
| hsa-miR-548w | 2,11 | 0,74 | ||||
| hsa-miR-339-3p | 2,05 | 0,74 | ||||
| hsa-miR-133a-3p | 2,04 | 0,75 | ||||
| HD/CTR | hsa-miR-576-3p | 5,83 | 0,84 | hsa-miR-30b-3p | -2,18 | 0,15 |
| hsa-miR-1260a# | 5,48 | 0,85 | hsa-miR-30d-3p $ | -3,34 | 0,20 | |
| hsa-miR-4429# | 4,96 | 0,84 | ||||
| hsa-miR-1260b# | 4,62 | 0,84 | ||||
| hsa-miR-1244 | 4,19 | 0,87 | ||||
| hsa-miR-195-3p | 3,96 | 0,84 | ||||
| hsa-miR-1277-3p | 3,91 | 0,88 | ||||
| hsa-miR-4454 | 3,57 | 0,84 | ||||
| hsa-miR-34c-3p | 3,39 | 0,84 | ||||
| hsa-miR-323b-3p | 3,17 | 0,84 | ||||
| hsa-miR-141-3p | 2,84 | 0,89 | ||||
| hsa-miR-98-3p | 2,80 | 0,84 | ||||
| hsa-miR-376b-3p# | 2,75 | 0,84 | ||||
| hsa-miR-589-3p | 2,61 | 0,89 | ||||
| hsa-miR-450a-2-3p# | 2,54 | 0,84 | ||||
| hsa-miR-548l | 2,45 | 0,84 | ||||
| hsa-miR-412-3p | 2,37 | 0,84 | ||||
| hsa-let-7i-3p | 2,36 | 0,84 | ||||
| hsa-miR-122-3p # | 2,29 | 0,85 | ||||
| hsa-miR-34a-3p | 2,28 | 0,84 | ||||
| hsa-miR-365a-3p | 2,14 | 0,84 | ||||
| hsa-miR-365b-3p | 2,14 | 0,84 | ||||
| hsa-miR-296-3p | 2,06 | 0,90 | ||||
| HD/pHD | hsa-miR-1260a | 11,43 | 0,63 | hsa-miR-184 | -7,54 | 0,63 |
| hsa-miR-5100 | 8,80 | 0,63 | hsa-miR-129-2-3p | -4,98 | 0,63 | |
| hsa-miR-4429 | 6,07 | 0,63 | hsa-miR-210-3p | -4,84 | 0,64 | |
| hsa-miR-19a-3p | 5,05 | 0,63 | hsa-miR-1228-3p | -3,59 | 0,63 | |
| hsa-miR-1260b | 3,58 | 0,63 | hsa-miR-940 | -2,57 | 0,63 | |
| hsa-miR-6529-3p | 3,26 | 0,63 | hsa-miR-500b-3p | -2,53 | 0,70 | |
| hsa-miR-23c | 3,13 | 0,63 | hsa-miR-133a-3p | -2,38 | 0,63 | |
| hsa-miR-122-3p | 3,02 | 0,63 | hsa-miR-30c-1-3p | -2,37 | 0,70 | |
| hsa-miR-19b-3p | 2,88 | 0,63 | hsa-miR-1270 | -2,33 | 0,70 | |
| hsa-miR-483-3p | 2,47 | 0,63 | hsa-miR-4510 | -2,28 | 0,66 | |
| hsa-miR-1180-3p | 2,38 | 0,63 | hsa-miR-1304-3p | -2,15 | 0,63 | |
| hsa-miR-671-3p | 2,33 | 0,63 | hsa-miR-377-3p | -2,14 | 0,72 | |
| hsa-miR-1303 | 2,19 | 0,63 | hsa-miR-708-3p | -2,03 | 0,63 | |
| hsa-miR-26b-3p | 2,16 | 0,63 | ||||
| hsa-miR-450a-2-3p | 2,16 | 0,63 | ||||
| hsa-miR-376b-3p | 2,12 | 0,63 | ||||
| hsa-miR-585-3p | 2,07 | 0,63 | ||||
| hsa-miR-590-3p | 2,02 | 0,63 | ||||
Data are shown as fold-change relative to control group
* Overexpressed miR in common between pHD/CTR and HD/CTR
# Overexpressed miR in common between HD/CTR and HD/pHD
$ Underexpressed miR in common between pHD/CTR and HD/CTR