Table 2.
List of significantly up- and down-regulated microRNAs, or those exclusive of fpHD3- and fCTR1-derived EVs, with previously validated targets that modulate GABAergic synapses.
| miRNAs | Expression | Experimentally identified targets | Involved proteins/pathways | |
|---|---|---|---|---|
| miR-365a-3p | ↑ fpHD3 | ↑ miR ➔ ↓GABAAR-δ (83) |
GABAergic receptor | |
| miR-195-3p | ↑ fpHD3 | ↑ miR ➔ ↓ST6GAL1 (86) |
Interplay with L1, a neural cell adhesion molecule that increases the differentiation into GABAergic neurons and the yield in mediumspiny GABAergic neurons in a HD mouse model* (87, 88) | |
| miR-210-3p | ↑ fpHD3 | ↑ miR ➔ ↓BDNF (85, 89) |
GABAergic synapse assembly | |
| mir-889-3p | ↑ fpHD3 | ↑ miR ➔ ↓WNT7A (90) |
GABAergic synapse assembly | |
| miR-129-2-3p | Exclusive fpHD3 | ↑ miR ➔ ↓GABRA1 (84) |
GABAergic receptor | |
| miR-19a-3p | Exclusive fCTR1 | ↑ miR ➔ ↓TGF-β R II (91) |
Removal of TGF-β R II leads to an increase in GABAergic inhibitory input to DA neurons, the ratio of inhibitory/excitatory synapses, and mIPSC frequency (92) | |
| miR-2110 | Exclusive fCTR1 | ↑ miR ➔ ↑Neurotensin receptor type 1 (93) |
Increase in striatal GABA release (96) | |
| miR-941 | Exclusive fCTR1 | ↑ miR ➔ ↓ DNAJC5 (94) |
GABAergic synaptic vesicles | |
| miR-1180-3p | Exclusive fCTR1 | ↑ miR ➔ ↓ Dlx1 (95) |
GABAergic neurogenesis |
* L1 upregulates the expression of ST6GAL1 mRNA levels and L1-mediated embryonic stem cell survival is through induction of ST6GAL1 expression, making this a possible pathway that might be involved in GABAergic neurogenesis. However, to the best of our knowledge, the direct link between L1-dependent effects on the development of GABAergic neurons and ST6GAL1 has not been yet studied.