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. 2023 Jul 10;15(1):2231596. doi: 10.1080/19490976.2023.2231596

Figure 4.

Figure 4.

Effects of delivery mode and feeding on infant fecal metabolism and gut microbiota, and the association of short-chain acylcarnitines at birth with infant growth. (a) Heatmap of variation in fecal metabolites in the NB, 4 M and 12 M groups based on delivery mode. The ratio of the relative content of each metabolite between the different groups was calculated and converted logarithmically to make a heatmap. Asterisks (*) indicate metabolites with |Log2 FC| > 1.0 and FDR < 0.05. (b) Impact of feeding on the variations in acylcarnitines, bile acids and tryptophan metabolites with age in vaginal infants. (c) Heatmap of the Spearman correlation coefficients between acylcarnitines at birth and infant weight gain during the first year of life. Asterisks (*) indicate a significant correlation (p < 0.05). (d) Boxplots of the correlation between shorth-chain acylcarnitines and infant growth from birth to 12 months old (*p < 0.05). (e) Discriminative bacteria based on delivery mode in the Chinese and Swedish cohorts. (f) Discriminative bacteria based on levels of short-chain acylcarnitines. Data are represented as mean ± SEM. Short-chain acylcarnitines were tertiled based on the relative abundance, separately. T1 indicates the lowest tertile and T3 indicates the highest tertile (*p < 0.05 and LDA score above 2).