Table 1.
Summary of search results by dermatologic condition.
| Dermatologic condition | Number of studies | Weighted mean prevalence,a % (n/N) | ||||
|
|
Case report, n | CS/Cohort,b n | Observational, n |
|
||
| Inflammatory skin conditions | ||||||
|
|
Acne vulgaris | 0 | 0 | 7 | 14.7 (149/1017) | |
|
|
Atopic dermatitis | 2 | 0 | 6 | 19.7 (178/903) | |
|
|
Cheilitis | 0 | 0 | 6 | 8.4 (68/805) | |
|
|
Folliculitis | 1 | 0 | 7 | 21.2 (213/1006) | |
|
|
Hidradenitis suppurativa | 2 | 1 | 6 | 3.2 (425/13266) | |
|
|
Ichthyosis | 2 | 0 | 2 | 4.7 (14/298) | |
|
|
Keratosis pilaris | 0 | 0 | 9 | 8.6 (97/1134) | |
|
|
Lichen nitidus | 5 | 0 | 1 | 1.1 (—c) | |
|
|
Pityriasis rubra pilaris | 3 | 0 | 0 | — | |
|
|
Psoriasis | 14 | 1 | 6 | 4.8 (46/953) | |
|
|
Seborrheic dermatitis | 0 | 0 | 8 | 18.5 (212/1149) | |
| Autoimmune skin conditions | ||||||
|
|
Alopecia areata | 11 | 5 | 11 | 7.4 (190/2574) | |
|
|
Vitiligo | 3 | 0 | 5 | 4.4 (31/709) | |
| Infectious skin conditions | ||||||
|
|
Leishmaniasis | 4 | 0 | 0 | — | |
|
|
Onychomycosis | 0 | 2 | 3 | 24.7 (188/761) | |
|
|
Scabies | 7 | 0 | — | — | |
|
|
Tinea capitis | 0 | 0 | 1 | 2.5 (6/243) | |
|
|
Tinea corporis | 0 | 0 | 2 | 2.0 (9/446) | |
|
|
Tinea cruris | 0 | 0 | 1 | 8.4 (18/214) | |
|
|
Tinea pedis | 0 | 0 | 4 | 30.9 (190/615) | |
| Cutaneous birthmarks, tumors, and depositions | ||||||
|
|
Café au lait macules | 0 | 0 | 5 | 3.8 (24/633) | |
|
|
Calcinosis cutis | 13 | 1 | 1 | 3.0 (—) | |
|
|
Connective tissue nevi | 6 | 0 | 0 | — | |
|
|
Dermatofibroma | 3 | 0 | 0 | — | |
|
|
Melanoma | 3 | 0 | 0 | — | |
|
|
Syringoma | 8 | 0 | 6 | 21.2 (174/821) | |
| Other skin conditions | ||||||
|
|
Acanthosis nigricans | 0 | 0 | 3 | 30.7 (67/218) | |
|
|
Cutis marmorata | 0 | 0 | 3 | 8.4 (28/335) | |
|
|
EPSd | 16 | 2 | 1 | 0.5 (1/203) | |
|
|
Other case reportse | 7 | — | — | — | |
aWeighted mean prevalence of patients with dermatologic condition in a population with Down syndrome, calculated from values reported in observational studies.
bCS/Cohort: Case series or cohort studies with no prevalence value provided.
cNot available.
dEPS: elastosis perforans serpiginosa.
eOther case reports examined patients with actinomycetoma, cheilitis granulomatosa, epidermolysis bullosa, generalized perforating granuloma annulare, keratosis follicularis spinulosa decalvans, reactive perforating collagenosis, and familial urticaria pigmentosa.