Table 8.
Summary of results and overall risk of bias for studies conducted during among vegetarians, including vegans
| Author, year Study design | Results B12, pmol/L | Results MMA μmol/L | Hcy, μmol/L | Holo-TC, pmol/L | Risk of bias |
|---|---|---|---|---|---|
| Kwok 2012 RCT (34) |
Baseline mean (SD): 134 (126) Endpoint (12 week) mean (SD): 500 μg: 379.6 (206.2) Placebo: 185.7 (145.4) |
Baseline mean (SD): 16.7 (11.0) Endpoint (12 week) mean (SD): 500 μg: 11.3 (6.0) Placebo: 13.1 (5.0) |
- | Low | |
| Obersby 2015 RCT (35) |
- | - |
Baseline mean (SD): ITT 500 μg/d: 14.7 (3.7) Placebo: 14.1 (2.8) Completers: 500 μg/d: 15.5 (3.7) Placebo: 13.7 (2.6) Endpoint mean (SD): ITT 500 μg/d: 9.1 (3.1) Placebo: 12.9 (4.5) Completers: 500 μg/d: 8.4 (3.1) Placebo: 12.5 (4.5) |
- | High |
| Lederer 2019 RCT (36) |
Baseline mean (SD)**: Vegan: 161.5 (49.4) Meat: 174.1 (70.9) Endpoint mean (SD)**: Vegan: 131.8 (41.9) Meat: 174.4 (63.6) |
Baseline mean (SD) nmol/L: Vegan: 214.5 (129.6) Meat: 220.0 (121.0) Endpoint mean (SD) nmol/L: Vegan: 277.8 (330.0) Meat: 213.1 (182.2) |
Values not stated |
Baseline mean (SD): Vegan: 67.3 (23.5) Meat: 69.7 (29.7) Endpoint mean (SD): Vegan: 43.6 (20.0) Meat: 64.4 (28.7) |
Some concerns |
| Del Bo 2019 RCT (37) |
Baseline mean (SD): 350 μg/w: 146 (36) 2000 μg/w: 131 (56) Endpoint (90 d) mean*: 350 μg/w: 173 2000 μg/w: 200 |
Baseline mean: 350 μg/w: 1.1 2000 μg/w: 1.3 Endpoint (90 d) mean*: 350 μg/w: 0.3 2000 μg/w: 0.4 |
Baseline mean: 350 μg/w: 16 2000 μg/w: 18 Endpoint (90 d) mean*: 350 μg/w: 8.0 2000 μg/w: 8.5 |
Baseline mean: 350 μg/w: 57 2000 μg/w: 45 Endpoint (90 d) mean*: 350 μg/w: 96 2000 μg/w: 122 |
Low |
*
Estimated from figure by Graphreader.com.
**
Converted from ng/mL.