Table 1.
Comparison of demographic, treatment and pathology characteristics between octogenarians and controls
| Demographics | Total n = 220 |
Controls n = 110 |
Octogenarians n = 110 |
P |
|---|---|---|---|---|
| Age (years), median (range) | 79 (36–88) | 69 (36–79) | 81 (80–86) | <0.001* |
| Sex | 0.135 | |||
| Male | 123 (55.9) | 67 (60.9) | 56 (50.9) | |
| Female | 97 (44.1) | 43 (39.1) | 54 (49.1) | |
| Charlson co-morbidity index | <0.001* | |||
| 1–2 | 6 (2.7) | 6 (5.5) | 0 | |
| 3–4 | 34 (15.5) | 34 (30.9) | 0 | |
| >5 | 167 (75.9) | 62 (56.4) | 105 (95.5) | |
| ECOG performance status | 0.756 | |||
| 0–1 | 197 (89.5) | 98 (89.1) | 99 (90) | |
| 2–4 | 9 (4.1) | 4 (3.6) | 5 (4.5) | |
| ASA | 0.635 | |||
| I–II | 149 (67.7) | 77 (70) | 72 (65.5) | |
| III–IV | 38 (17.3) | 18 (16.4) | 20 (18.2) | |
| Treatment | ||||
| Neoadjuvant therapy | ||||
| Chemotherapy | 5 (2.3) | 3 (2.7) | 2 (1.8) | 0.651 |
| Radiotherapy | 3 (1.4) | 2 (1.8) | 1 (0.9) | 0.561 |
| Operation | 0.786 | |||
| Whipples | 122 (55.5) | 60 (54.5) | 62 (56.4) | |
| PPPD | 98 (44.5) | 50 (45.5) | 48 (43.6) | |
| Vein resection | 54 (24.5) | 28 (25.5) | 26 (23.6) | 0.754 |
| Adjuvant chemotherapy | 138 (62.7) | 80 (72.7) | 58 (52.7) | 0.006* |
| Pathology | ||||
| T stage | 0.271 | |||
| pT1 | 8 (3.6) | 3 (2.7) | 5 (4.6) | |
| pT2 | 10 (4.5) | 7 (6.4) | 3 (2.7) | |
| pT3 | 197 (89.6) | 99 (90) | 98 (89.1) | |
| pT4 | 5 (2.3) | 1 (0.9) | 4 (3.6) | |
| Resection margin | 0.499 | |||
| R0 | 101 (45.9) | 48 (43.6) | 53 (48.2) | |
| R1 | 119 (54.1) | 62 (56.4) | 57 (51.8) | |
| Lymph node ratio, median (range) | 0.15 (0–1) | 0.19 (0–1) | 0.14 (0–0.75) | 0.132 |
| Perineural invasion | 187 (85) | 93 (84.5) | 94 (85.5) | 0.278 |
| Perivascular invasion | 171 (77.7) | 84 (76.4) | 87 (79.1) | 0.183 |
| Outcomes | ||||
| 30-day mortality | 5 (2.3) | 2 (1.8) | 3 (2.7) | 0.636 |
| 90-day mortality | 13 (5.9) | 4 (3.6) | 9 (8.2) | 0.143 |
Values are n (%) unless otherwise stated. *P values are significant. ECOG, Eastern Cooperative Oncology Group; PPPD, pylorus-preserving pancreatoduodenectomy.