Table 3.
Genetic Model Analyses of the Association Between Three SNPs and the Risk of Stroke (Adjusted by Age and Gender)
| SNP-ID | Model | Genotype | Case (%) | Control (%) | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| rs369149111 HTRA1 |
Genotype | TT | 5 (0.8%) | 6 (1.1%) | 0.77 (0.23–2.55) | 0.673 |
| TC | 102 (16.5%) | 89 (15.6%) | 1.08 (0.79–1.47) | 0.650 | ||
| CC | 511 (82.7%) | 476 (83.4%) | 1.00 | 0.819 | ||
| Dominant | TT+TC | 107 (17.3%) | 95 (16.6%) | 1.06 (0.78–1.43) | 0.728 | |
| CC | 511 (82.7%) | 476 (83.4%) | 1.00 | |||
| Recessive | TT | 5 (0.8%) | 6 (1.1%) | 0.76 (0.23–2.52) | 0.659 | |
| TC+CC | 613 (99.2%) | 565 (99%) | 1.00 | |||
| Additive | / | / | / | 1.03 (0.78–1.37) | 0.828 | |
| rs1803628 GAS6 |
Genotype | AA | 24 (3.9%) | 19 (3.3%) | 0.77 (0.23–2.55) | 0.673 |
| AG | 181 (29.2%) | 158 (27.8%) | 1.08 (0.79–1.47) | 0.650 | ||
| GG | 414 (66.9%) | 392 (68.9%) | 1.00 | 0.819 | ||
| Dominant | AA+AG | 205 (33.1%) | 177 (31.1%) | 1.09 (0.85–1.39) | 0.508 | |
| GG | 414 (66.9%) | 392 (68.9%) | 1.00 | |||
| Recessive | AA | 24 (3.9%) | 19 (3.3%) | 1.19 (0.64–2.19) | 0.588 | |
| AG+GG | 595 (96.1%) | 550 (96.7%) | 1.00 | |||
| Additive | / | / | / | 1.08 (0.88–1.33) | 0.455 | |
| rs9808753 IFNGR2 |
Genotype | GG | 130 (20.9%) | 90 (15.8%) | 1.59 (1.14–2.23) | 0.007 |
| GA | 311 (49.9%) | 280 (49.1%) | 1.21 (0.94–1.57) | 0.140 | ||
| AA | 182 (29.2%) | 200 (35.1%) | 1.00 | 0.024 | ||
| Dominant | GG+GA | 441 (70.8%) | 370 (64.9%) | 1.31 (1.02–1.67) | 0.032 | |
| AA | 182 (29.2%) | 200 (35.1%) | 1.00 | |||
| Recessive | GG | 130 (20.9%) | 90 (15.8%) | 1.42 (1.05–1.91) | 0.022 | |
| GA+AA | 493 (79.1%) | 480 (84.2%) | 1.00 | |||
| Additive | / | / | / | 1.26 (1.07–1.48) | 0.007 |
Notes: p values were calculated by Wald test under logistic regression. p < 0.05 in bold type indicates statistical significance.
Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.