Table 4.
Distribution of SNPs in Different Age, Gender, Smoking Status, Drinking Status and Its Association with Risk of Stroke
| SNP-ID | Model | Genotype | Case | Control | OR (95% CI) | p | Case | Control | OR (95% CI) | p |
|---|---|---|---|---|---|---|---|---|---|---|
| Smoking status | Smoking | Non-smoking | ||||||||
| rs1803628 | Genotype | AA | 10 (3%) | 10 (3.7%) | 0.79 (0.32–1.94) | 0.606 | 14 (4.8%) | 9 (3%) | 1.83 (0.77–4.34) | 0.168 |
| GAS6 | AG | 82 (24.9%) | 78 (28.8%) | 0.80 (0.56–1.16) | 0.239 | 99 (34.1%) | 80 (26.9%) | 1.45 (1.01–2.07) | 0.042 | |
| GG | 237 (72%) | 183 (67.5%) | 1.00 | 0.463 | 177 (61%) | 209 (70.1%) | 1.00 | 0.068 | ||
| Dominant | AA+AG | 92 (28%) | 88 (32.5%) | 0.80 (0.56–1.14) | 0.215 | 113 (39%) | 89 (29.9%) | 1.49 (1.06–2.09) | 0.023 | |
| GG | 237 (72%) | 183 (67.5%) | 1.00 | 177 (61%) | 209 (70.1%) | 1.00 | ||||
| Recessive | AA | 10 (3%) | 10 (3.7%) | 0.84 (0.34–2.05) | 0.695 | 14 (4.8%) | 9 (3%) | 1.63 (0.69–3.83) | 0.263 | |
| AG+GG | 319 (97%) | 261 (96.3%) | 1.00 | 276 (95.2%) | 289 (97%) | 1.00 | ||||
| Additive | / | / | / | 0.83 (0.62–1.13) | 0.236 | / | / | 1.41 (1.05–1.89) | 0.021 | |
| Age | Age ≤ 64 | Age > 64 | ||||||||
| rs9808753 IFNGR2 |
Genotype | GG | 70 (21.6%) | 58 (16.7%) | 1.65 (1.01–2.71) | 0.046 | 60 (20.1%) | 32 (14.4%) | 1.50 (0.86–2.6) | 0.152 |
| GA | 164 (50.6%) | 167 (48%) | 1.31 (0.88–1.93) | 0.181 | 147 (49.2%) | 113 (50.9%) | 1.04 (0.69–1.57) | 0.849 | ||
| AA | 90 (27.8%) | 123 (35.3%) | 1.00 | 0.125 | 92 (30.8%) | 77 (34.7%) | 1.00 | 0.316 | ||
| Dominant | GG+GA | 234 (72.2%) | 225 (64.7%) | 1.40 (0.97–2.03) | 0.076 | 207 (69.2%) | 145 (65.3%) | 1.14 (0.77–1.68) | 0.504 | |
| AA | 90 (27.8%) | 123 (35.3%) | 1.00 | 92 (30.8%) | 77 (34.7%) | 1.00 | ||||
| Recessive | GG | 70 (21.6%) | 58 (16.7%) | 1.41 (0.91–2.17) | 0.122 | 60 (20.1%) | 32 (14.4%) | 1.46 (0.89–2.39) | 0.132 | |
| GA+AA | 254 (78.4%) | 290 (83.3%) | 1.00 | 239 (79.9%) | 190 (85.6%) | 1.00 | ||||
| Additive | / | / | / | 1.29 (1.01–1.65) | 0.042 | / | / | 1.19 (0.91–1.55) | 0.201 | |
| Gender | Females | Males | ||||||||
| rs9808753 IFNGR2 |
Genotype | GG | 48 (21%) | 43 (18.3%) | 1.33 (0.79–2.24) | 0.285 | 82 (20.8%) | 47 (14%) | 1.82 (1.17–2.84) | 0.008 |
| GA | 111 (48.5%) | 109 (46.4%) | 1.21 (0.80–1.83) | 0.366 | 200 (50.8%) | 171 (51%) | 1.22 (0.88–1.70) | 0.232 | ||
| AA | 70 (30.6%) | 83 (35.3%) | 1.00 | 0.509 | 112 (28.4%) | 117 (34.9%) | 1.00 | 0.029 | ||
| Dominant | GG+GA | 159 (69.4%) | 152 (64.7%) | 1.24 (0.84–1.83) | 0.271 | 282 (71.6%) | 218 (65.1%) | 1.35 (0.99–1.85) | 0.059 | |
| AA | 70 (30.6%) | 83 (35.3%) | 1.00 | 112 (28.4%) | 117 (34.9%) | 1.00 | ||||
| Recessive | GG | 48 (21%) | 43 (18.3%) | 1.19 (0.75–1.88) | 0.465 | 82 (20.8%) | 47 (14%) | 1.61 (1.09–2.39) | 0.017 | |
| GA+AA | 181 (79%) | 192 (81.7%) | 1.00 | 312 (79.2%) | 288 (86%) | 1.00 | ||||
| Additive | / | / | / | 1.16 (0.89–1.49) | 0.257 | / | / | 1.33 (1.07–1.65) | 0.009 | |
| Drinking status | Drinking | Non-drinking | ||||||||
| rs9808753 IFNGR2 |
Genotype | GG | 58 (18.7%) | 29 (11.3%) | 2.21 (1.30–3.74) | 0.003 | 72 (23%) | 61 (19.5%) | 1.30 (0.83–2.03) | 0.249 |
| GA | 161 (51.9%) | 128 (49.8%) | 1.38 (0.95–1.98) | 0.089 | 150 (47.9%) | 152 (48.6%) | 1.08 (0.75–1.56) | 0.667 | ||
| AA | 91 (29.4%) | 100 (38.9%) | 1.00 | 0.012 | 91 (29.1%) | 100 (31.9%) | 1.00 | 0.507 | ||
| Dominant | GG+GA | 219 (70.7%) | 157 (61.1%) | 1.53 (1.08–2.17) | 0.018 | 222 (70.9%) | 213 (68%) | 1.15 (0.81–1.61) | 0.437 | |
| AA | 91 (29.4%) | 100 (38.9%) | 1.00 | 91 (29.1%) | 100 (31.9%) | 1.00 | ||||
| Recessive | GG | 58 (18.7%) | 29 (11.3%) | 1.83 (1.13–2.95) | 0.014 | 72 (23%) | 61 (19.5%) | 1.24 (0.84–1.82) | 0.278 | |
| GA+AA | 252 (81.3%) | 228 (88.7%) | 1.00 | 241 (77%) | 252 (80.5%) | 1.00 | ||||
| Additive | / | / | / | 1.46 (1.14–1.87) | 0.003 | / | / | 1.14 (0.91–1.41) | 0.261 | |
Notes: p values were calculated by Wald test under logistic regression with adjustment for gender and age. p < 0.05 in bold type indicates statistical significance.
Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.