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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Gastroenterology. 2023 Mar 7;164(7):1279–1292. doi: 10.1053/j.gastro.2023.02.043

Figure 6. TEAD inhibitors suppressed HCC development.

Figure 6.

A,B. Huh7 cells were treated with pan-TEAD inhibitor VT104 for 72h (A) followed by WST assay to assess cell number or for 24h for qPCR of ANKRD1, ANLN and KIF23. C,D. Representative images, LW/BW ratio, tumor number and size and CTNNB1-Myc-Tag-positive area from C57BL/6J mice after HTVI of MET+CTNNB1-S45Y, followed by treatment with vehicle (n=16), pan-TEAD inhibitors VT104 (n=16, 10 mg/kg/day) or VT107 (n=15, 30 mg/kg/day) for 6 weeks (C) as well as representative images and quantification of Ki67 and γH2AX staining after treatment with vehicle (n=8) or pan-TEAD inhibitors VT104 (n=7) or VT107 (n=7) for 2 weeks (D). Scale bar (C): 1 cm, (D): 100μm.