Table 1.
Clearance of adult worms and microfilariae after OXF treatment.
| Adult worm negative mice | Microfilariae negative mice | |||||
|---|---|---|---|---|---|---|
| Vehicle | 5 mg/kg OXF | 12.5 mg/kg OXF | Vehicle | 5 mg/kg OXF | 12.5 mg/kg OXF | |
| BALB/c | 0.0% | 23.8% | 44.4% | 44.4% | 85.7% | 96.2% |
| (0/27) | (5/21) | (12/27) | (12/27) | (18/21) | (26/27) | |
| ΔdblGata1 | 0.0% | 9.0% | 11.1% | 70.0% | 54.5% | 44.4% |
| (0/10) | (1/11) | (1/9) | (7/10) | (6/11) | (4/9) | |
| IL-4r/ IL-5−/− | 0.0% | 8.3% | 0.0% | 8.3% | 16.60% | 7.6% |
| (0/12) | (1/12) | (0/13) | (1/12) | (2/12) | (1/13) | |
| Rag2/ IL-2rγ−/− | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| (0/6) | (0/5) | (0/3) | (0/6) | (0/5) | (0/3) | |
| μMT | 0.0% | 0.0% | 12.5% | 30.0% | 100% | 100% |
| (0/10) | (0/8) | (1/8) | (3/10) | (8/8) | (8/8) | |
BALB/c WT mice and immunodeficient strains (ΔdblGata1, IL-4r/IL-5−/−, μMT, and Rag2/IL-2rγ−/−) were naturally infected with Litomosoides sigmodontis and treated with 5 or 12.5 mg/kg OXF twice per day for 5 days starting 35 dpi. Number of adult worms in the thoracic cavity and number of microfilariae per 50 μL blood were quantified 70 dpi. Data is pooled from 2 to 6 experiments. Shown is the number and frequency of animals that were free of adult worms and microfilariae at 70 dpi.