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. 2023 Jun 27;14:1203534. doi: 10.3389/fendo.2023.1203534

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Copyright © 2023 Iwasaki, Lalani, Kahng, Carapeto, Sanjines, Hela, Abarca, Tsuji, Darcy, Bartke, Tseng, Kulkarni and Aguayo-Mazzucato

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased INS/IGF1R in β-cells from Dwarf^+/+ was accompanied by decreased senescence marker P21^CIP1. (A–C) Differences in blood glucose, body weight, and pancreas weight between Dwarf^+/+ (10 male/8 female, 11–14/9–34 months) and Dwarf^+/− (5 male/4 female, 11–14/12–14 months) mice. (D, E) Circulating IGF1 and insulin levels between Dwarf^+/+ and Dwarf^+/− mice. (F–I′) Immunostaining of islets from Dwarf^+/+ (5 males at 11–13 weeks) and Dwarf^+/− (5 males at 11–14 weeks) mice showing insulin (red/green) in islets, DNA stained with DAPI (blue), IGF1R (F–G′) in green, and P21 (H–I′) in red. The white scale bars represent 100 μm. Image analysis to quantify the intensity differences of IGF1R (J), INSULIN (K), and P21CIP1 (L) between islets from Dwarf^+/+ and Dwarf^+/− mice, using t-test, with ***p < 0.001 and ****p < 0.0001, respectively. ns, not significant.