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. 2023 Jun 27;14:1203534. doi: 10.3389/fendo.2023.1203534

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Copyright © 2023 Iwasaki, Lalani, Kahng, Carapeto, Sanjines, Hela, Abarca, Tsuji, Darcy, Bartke, Tseng, Kulkarni and Aguayo-Mazzucato

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-seq from islets with downregulation of Igf1r revealed decreased markers of senescence and increased expression of β-cell identity genes. Heatmaps and Z-score average expression data from RNA-seq of islets of βIgf1rKD and βIgf1r mice showing changes in senescence signature genes (A, B) and key β-cell function and hallmark genes (C, D). Differential gene expression of p16^Ink4a (E) per animal. (F) Reactome pathway analysis of genes differentially expressed in βIgf1rKD and βIgf1r. Male and female at the age of 17 months, with four mice per group, ****p < 0.0001.