Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 27;14:1203534. doi: 10.3389/fendo.2023.1203534

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Iwasaki, Lalani, Kahng, Carapeto, Sanjines, Hela, Abarca, Tsuji, Darcy, Bartke, Tseng, Kulkarni and Aguayo-Mazzucato

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Suggested model of the interaction between Igf1r and senescence in adult mouse β-cells. Our results suggest that downregulation of Igf1r in senescent β-cell leads to decreased p16 gene expression and p21 protein levels, both markers and effectors of senescence, decreased gene expression of senescence-associated secretory phenotype (SASP) factors in a model of a high-fat diet, and improved glucose clearance and restored loss of glucose responsiveness compared to βIgf1r (control) in intraperitoneal glucose tolerance test (IPGTT). Created with BioRender.com.