Table 2.

Multivariable model for our primary CD outcome measure and selected variables

Independent variable	Multivariable analysis
	OR	Lower 95% CI of OR	Upper 95% CI of OR	P value
Female versus male	0.28	0.07	1.20	0.09
Caucasian versus non-Caucasian	0.19	0.08	0.48	<0.01*
Employed or student versus others	0.33	0.13	0.83	0.02*
College or university degree	0.38	0.13	1.13	0.08
Fatigue Severity Scale (FSS score)	1.33	1.07	1.64	<0.01*
Cumulative dose of azathioprine (g/kg)	0.70	0.53	0.91	<0.01*
Immunosuppressive use excluding AZA	0.43	0.18	1.02	0.06

Selected out of the model: use of cACEi/cARB and cumulative dose of cACEi/cARB.

*Statistically significant, p-value ≤0.05.

AZA, azathioprine; cACEi, centrally acting ACE inhibitor; cARB, centrally acting angiotensin receptor blocker; CD, cognitive dysfunction.