TABLE 1.

The kinetics models used to fit the silibinin release data from MNNPs at different pHs. The bold values indicated the best fitted models.

Kinetics model	Equation	Coefficient of determination (R 2)
		pH = 5.8	pH = 7.4
Zero order	$F=k_{0}t$	0.7542	0.7274
First order	$\ln \left(1-F\right)=-k_{f}t$	0.8673	0.7959
Higuchi	$F=k_H\sqrt{t}$	0.9030	0.8896
Power law	$\ln F=\ln k_P+P\ln t$	0.9506	0.9627
Square root of mass	$1-\sqrt{1-F}=k_{1/2}t$	0.8131	0.7622
Hixson-Crowell	$1-\sqrt[3]{1-F}=k_{1/3}t$	0.8319	0.7736
Three seconds’ root of mass	$1-\sqrt[3]{{\left(1-F\right)}^2}=k_{2/3}t$	0.7937	0.7507
Weibull	$\ln \left(-\ln \left(1-F\right)\right)=-\beta \ln t_d+\beta \ln t$	0.9462	0.9208
Reciprocal powered time	$\left(\frac{1}{F}-1\right)=\frac{m}{t^b}$	0.9610	0.9365