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Inhibition of GLP-1-stimulated cAMP production by GLE analogues.
| GLP-1R cAMP Production Inhibition |
||
|---|---|---|
| Peptide | IC50 (nM) | IC50 relative |
| Ex(9-39) | 16 | 1 |
| GLE L-Ala | 330 | 21 |
| GLE (S,S)-ACPC | 23 | 1 |
| GLE (R,R)-ACPC | 150 | 9 |
| GLE β-hGly | 280 | 18 |
IC50 values are the average of 4 independent experiments. IC50 relative indicates the GLE analogue’s ability to inhibit GLP-1-stimulated cAMP production normalized to the inhibition by Ex(9-39): (GLE analogue/Ex(9-39)).
