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. 2022 May 5;64(6):366–371. doi: 10.11622/smedj.2022042

Table 1.

Literature review of 32 cases of SARS-CoV-2 vaccination associated myocarditis.,[4,5,6,7,8,9,10,11]

Study Age (yr)/gender Type of vaccine/dose/duration of symptoms onset (day) Presenting symptoms/troponin T ECG changes/type of ECG changes Echocardiogram, EF/cardiac MRI Management Outcome (duration of admission/survival)
Mouch et al.[11] 24/M Pfizer BNT/second/3 Chest pain/elevated Yes/diffuse ST elevation Normal, 63%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID + colchicine) <7 days/Yes

20/M Pfizer BNT/second/<1 Chest pain/elevated Yes/ST elevation V2-6 Normal, 55%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID + colchicine) <7 days/Yes

29/M Pfizer BNT/second/2 Chest pain/elevated Yes/diffuse ST elevation, diffuse PR depression Normal, 61%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID + colchicine) <7 days/Yes

45/M Pfizer BNT/ first/16 Chest pain/elevated Yes/ST elevation and depression Normal, 50%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID + colchicine) >7 days/Yes

16/M Pfizer BNT/second/<1 Chest pain/elevated Yes/ST elevation Normal, 59%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID + colchicine) <7 days/Yes

17/M Pfizer BNT/second/3 Chest pain, abdominal pain/elevated Yes/ST elevation Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID + colchicine) <7 days/Yes

Albert et al.[10] 24/M Moderna mRNA/second/4 Chest pain Yes/sinus tachycardia Normal, 65%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID); Anti-failure (B-blocker) NA/Yes

Rosner et al.[9] 28/M Johnson/ first/5 Chest pain, shortness of breath/elevated Yes/ST elevation Normal, 51%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (aspirin); Anti-failure (B-blocker, ACEI) <7 days/Yes

39/M Pfizer BNT/second/3 Chest pain, shortness of breath/elevated Yes/PR depression Reduced, 35%/suggestive MRI with myocardial oedema and LGE Anti-failure (B-Blocker, ARB) <7 days/Yes

39/M Moderna mRNA/second/4 Chest pain, shortness of breath/elevated No/- Normal, 61%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (IV steroid) <7 days/Yes

24/M Pfizer BNT/ first/7 Chest pain/elevated No/- Normal, 53%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (ibuprofen, colchicine) <7 days/Yes

19/M Pfizer BNT/second/2 Chest pain/elevated No/- Normal, 55%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (ibuprofen, colchicine) <7 days/Yes

20/M Pfizer BNT/second/3 Chest pain/elevated Yes/ST elevation Normal, 50%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (ibuprofen) <7 days/Yes

23/M Pfizer BNT/second/3 Chest pain/elevated Yes/diffuse ST elevation Normal, 58%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (colchicine); Anti-failure (B-blocker) <7 days/Yes

Marshall et al.[8] 16/M Pfizer BNT/second/2 Chest pain/elevated Yes/ST elevation, AV dissociation Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID, methylprednisolone, IVIG) <7 days/Yes

19/M Pfizer BNT/second/3 Chest pain/elevated Yes/diffuse ST elevation Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID, colchicine, aspirin) <7 days/Yes

17/M Pfizer BNT/second/2 Chest pain/elevated Yes/diffuse ST elevation, nonspecific T changes Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID) <7 days/Yes

18/M Pfizer BNT/second/2 Chest pain/elevated Yes/ST elevation Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID, methylprednisolone, IVIG) <7 days/Yes

17/M Pfizer BNT/second/4 Chest pain, shortness of breath/elevated Yes/nonspecific T changes Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID, aspirin, methylprednisolone, IVIG) <7 days/Yes

16/M Pfizer BNT/second/3 Chest pain, palpation, shortness of breath/elevated Yes/ST elevation Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (prednisolone, IVIG) <7 days/Yes

14/M Pfizer BNT/second/2 Chest pain, shortness of breath/elevated Yes/ST elevation Reduced, 47%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID); Anti-failure (furosemide) <7 days/Yes

McLean et al.[7] 16/M Pfizer BNT/second/2 Chest pain/elevated Yes/ST elevation Normal, 61%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID, IVIG) <7 days/Yes

Muthukumar et al.[6] 52/M Moderna mRNA/second/3 Chest pain/elevated Yes/right bundle branch block Normal, 54%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID); Anti-failure (carvedilol, lisinopril) <7 days/Yes

D’Angelo et al.[5] 30/M Pfizer BNT/second/3 Chest pain/elevated Yes/ST elevation, nonspecific T changes Normal, NA/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (aspirin); Anti-failure (bisoprolol, prednisolone) <7 days/Yes

Larson et al.[4] 22/M Moderna mRNA/second/3 Chest pain/elevated Yes/diffuse ST elevation Normal, 50%/suggestive MRI with myocardial LGE Anti-inflammatory (NASID, prednisolone) <7 days/Yes

31/M Moderna mRNA/second/3 Chest pain, shortness of breath/elevated No/- Reduced, 34%/suggestive MRI with myocardial LGE <7 days/Yes

40/M Pfizer BNT/ first/2 Chest pain/elevated Yes/diffuse ST elevation Reduced, 47%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (colchicine, prednisolone) <7 days/Yes

56/M Pfizer BNT/second/3 Chest pain/elevated Yes/nonspecific T changes Normal, 60%/suggestive MRI with myocardial oedema and LGE <7 days/Yes

26/M Pfizer BNT/second/3 Chest pain/elevated Yes/ST elevation Normal, 60%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (colchicine) <7 days/Yes

35/M Pfizer BNT/second/2 Chest pain/elevated Yes/diffuse ST elevation Normal, 50%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID) <7 days/Yes

21/M Pfizer BNT/second/4 Chest pain/elevated Yes/diffuse ST elevation Normal, 54%/suggestive MRI with myocardial oedema and LGE Anti-inflammatory (NASID) <7 days/Yes

22/M Moderna mRNA/second/2 Chest pain/elevated Yes/ST elevation Normal, 53%/suggestive MRI with myocardial oedema and LGE <7 days/Yes

ACEI: angiotensin-converting enzyme inhibitor, ARB: angiotensin receptor blocker, AV: atrial ventricle, IVIG: intravenous immunoglobulin, Johnson: Johnson & Johnson (Ad.26.COV2.S), LGE: late gadolinium enhancement, M: male, Moderna mRNA: ModernaTX (mRNA-1273), MRI: magnetic resonance imaging, NA: not available, NASID: non-steroidal anti-inflammatory drug, Pfizer BNT: Pfizer-BioNTech mRNA vaccine (BNT162b2)