Table 1.
Patients and disease characteristics at first relapse.
| Characteristic | ICE Group Number = 82 (%) |
GV Group Number = 50 (%) |
P-value |
|---|---|---|---|
| Sex | |||
| Male | 58 (70.7) | 32 (64) | 0.42 |
| Female | 24 (29.3) | 18 (36) | |
| Age (years) | |||
| <13 | 43 (52.4) | 19 (38) | 0.1 |
| ≥13 | 39 (47.6) | 31 (62) | |
| Histology | |||
| Nodular sclerosis | 44 (62.8) | 32 (66.7) | 0.75 |
| Others | 26 (37.2) | 16 (33.3) | |
| Missing | 12 (14.6) | 2 (4) | |
| Time to relapse | |||
| Refractory | 19 (23.2) | 12 (24) | 0.88 |
| Early relapse | 16 (19.5) | 8 (16) | |
| Late relapse | 47 (57.3) | 30 (60) | |
| Stage | |||
| I | 9 (11) | 3 (6) | 0.87 |
| II | 12 (14.6) | 10 (20) | |
| III | 19 (23.2) | 13 (26) | |
| IV | 42 (51.2) | 24 (48) | |
| Number of organs involved in stage 4 | |||
| 1 | 23 (54.8) | 14 (58.3) | 0.12 |
| 2 | 11 (26.2) | 10 (41.7) | |
| 3 | 6 (14.2) | 0 (0) | |
| 4 | 2 (4.8) | 0 (0) | |
| Bone marrow involvement~ | |||
| Present | 15 (18.3) | 12 (24) | 0.4 |
| Absent | 67 (81.7) | 38 (76) | |
| Bone involvement | |||
| Present | 18 (22) | 10 (20) | 0.9 |
| Absent | 64 (78) | 40 (80) | |
| Liver involvement | |||
| Present | 14 (17) | 4 (8) | 0.14 |
| Absent | 68 (83) | 46 (92) | |
| Lung involvement | |||
| Present | 24 (29.3) | 8 (16) | 0.06 |
| Absent | 58 (70.7) | 42 (84) | |
| B-symptoms | |||
| Present | 27 (45) | 16 (59.3) | 0.2 |
| Absent | 33 (55) | 11 (40.7) | |
| Missing | 22 (26.8) | 27 (54) | |
| Bulky disease | |||
| Present | 11 (13.4) | 7 (14) | 0.9 |
| Absent | 71 (86.6) | 43 (86) | |
| WBC × 10(3)/mcl | |||
| <13.5 | 63 (76.8) | 34 (68) | 0.27 |
| ≥13.5 | 19 (23.2) | 16 (32) | |
| Hemoglobin, gm/dl | |||
| <10.5 | 40 (48.8) | 23 (46) | 0.76 |
| ≥10.5 | 42 (51.2) | 27 (54) | |
| ESR (first hour), mm/h | |||
| <50 | 29 (40.3) | 18 (38.3) | 0.83 |
| ≥50 | 43 (59.7) | 29 (61.7) | |
| Missing | 10 (12.2) | 3 (6) | |
| LDH, IntUnit/L* | |||
| <700 | 56 (82.4) | 42 (89.4) | 0.3 |
| ≥700 | 12 (17.6) | 5 (10.6) | |
| Missing | 14 (17) | 3 (6) | |
| Albumin, gm/dl | |||
| <3.5 | 27 (64.3) | 4 (36.4) | 0.09 |
| ≥3.5 | 15 (35.7) | 7 (63.6) | |
| Missing | 40 (48.8) | 39 (78) | |
| Radiation therapy (first line) | |||
| No | 39 (47.6) | 15 (30) | 0.047 |
| Yes | 43 (52.4) | 35 (70) | |
ICE, ifosfamide, carboplatin, and etoposide; GV, gemcitabine and vinorelbine; WBC, white blood cell; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase. ~Bone Marrow Involvement by BMB and/or PET/CT. *LDH ≥ 1 × Normal (700 IntUnit/L). Percentages (%) and the P-value calculated on valid data only.