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. 2023 Jun 27;13:1153128. doi: 10.3389/fonc.2023.1153128

Table 2.

Response rate for the whole cohort before consolidation in relation to prognostic factors.

Characteristic Whole patients, number = 130 (%)
Response rate before consolidation, number (%) Total Univariate Multivariate
CR/PR PD P-value P-value
Regimen
 ICE 44 (54.3) 37 (45.7) 81 0.004 0.002
 GV 14 (28.6) 35 (71.4) 49
Sex
 Female 13 (31.7) 28 (68.3) 41 0.04 NS
 Male 45 (50.6) 44 (49.4) 89
Age (year)
 <13 44 (53) 39 (47) 83 0.01 NS
 ≥13 14 (29.8) 33 (70.2) 47
Time to relapse 0.002
 Refractory 3 (10.3) 26 (89.7) 29 0.0001 0.0001
 Early relapse 12 (50) 12 (50) 24 0.261
 Late relapse (ref) 43 (55.8) 34 (44.2) 77
Stage
 I 9 (75) 3 (25) 12 0.01 NS
 II 13 (59.1) 9 (40.9) 22
 III 16 (50) 16 (50) 32
 IV 20 (31.3) 44 (68.7) 64
Bone involvement
 Absent 48 (47.5) 53 (52.5) 101 0.2 NS
 Present 10 (34.5) 19 (65.5) 29
Bone marrow involvement ~
 Absent 49 (46.7) 56 (53.3) 105 0.34 NS
 Present 9 (36) 16 (64) 25
Lung involvement
 Absent 51 (51.5) 48 (48.5) 99 0.005 NS
 Present 7 (22.6) 24 (77.4) 31
Liver involvement
 Absent 55 (49.1) 57 (50.9) 112 0.01 NS
 Present 3 (16.7) 15 (83.3) 18
B-symptoms
 Absent 30 (68.2) 14 (31.8) 44 0.001 0.002
 Present 13 (31.7) 28 (68.3) 41
Bulky disease
 Absent 52 (46.4) 60 (53.6) 112 0.3 NS
 Present 6 (33.3) 12 (66.7) 18
Histology
 Nodular sclerosis 31 (41.9) 43 (58.1) 74 0.8 NS
 Others 18 (43.9) 23 (56.1) 41
ESR (first hour), mm/h
 <50 31 (66) 16 (34) 47 0.0001 NS
 ≥50 21 (30) 49 (70) 70
WBC, ×10(3)/mcl
 <13.5 49 (51) 47 (49) 96 0.01 NS
 ≥13.5 9 (26.5) 25 (73.5) 34
Hemoglobin, gm/dl
 <10.5 21 (33.9) 41 (66.1) 62 0.02 NS
 ≥10.5 37 (54.4) 31 (45.6) 68
Albumin, gm/dl
 <3.5 14 (48.3) 15 (51.7) 29 0.7 NS
 ≥3.5 12 (54.5) 10 (45.5) 22
LDH, IntUnit/L*
 <700 46 (47.4) 51 (52.6) 97 0.2 NS
 ≥700 5 (29.4) 12 (70.6) 17
Early response
 CR 43 (70.5) 18 (29.5) 61 0.0001 NS
 PR 15 (26.3) 42 (73.7) 57
 PD 0 (0) 12 (100) 12

ICE, ifosfamide, carboplatin, and etoposide; GV, gemcitabine and vinorelbine; WBC, white blood cell; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase; CR, complete response; PR, partial response; PD, progressive disease; NS, not significant.

~Bone marrow involvement by bone marrow biopsy and/or PET/CT. *LDH ≥ 1 × Normal (700 IntUnit/L).