Table 1. – Morphometrical data of rats receiving dutasteride, tamsulosin or the association of both.
| C | D | T | DT | p value* | |
|---|---|---|---|---|---|
| Initial body weight (g) | 286.6 ± 9.0 | 287.8 ± 21.5 | 288.0 ± 9.5 | 293.4 ± 13.4 | 0.724 |
| Final body weight (g) | 321.5 ± 5.4 | 333.4 ± 9.2 | 324.8 ± 11.0 | 322.1 ± 16.9 | 0.094 |
| Cross-sectional penile area (mm2) | 4.83 ± 0.56 | 4.05 ± 0.25 a | 3.98 ± 0.41 a | 3.54 ± 0.23 a | <0.0001 |
| Area of the corpus cavernosum - including tunica albuginea (mm2) | 3.33 ± 0.34 | 2.79 ± 0.19 a | 2.84 ± 0.32 a | 2.39 ± 0.18 a, b, c | <0.0001 |
| Area of the corpus cavernosum - without tunica albuginea (mm2) | 2.00 ± 0.17 | 1.90 ± 0.09 | 1.77 ± 0.24 a | 1.56 ± 0.14 a, b | <0.0001 |
| Area of the tunica albuginea (mm2) | 1.33 ± 0.24 | 0.96 ± 0.04 a | 1,07 ± 0.13 a | 0.88 ± 0.10 a | <0.0001 |
| Connective tissue Sv (%) | 46.44 ± 3.75 | 66.69 ± 4.23 a | 61.44 ± 5.57 a | 70.08 ± 3.64 a, c | <0.0001 |
| Sinusoidal space Sv (%) | 30.18 ± 4.85 | 21.38 ± 3.44 a | 22.13 ± 3.77 a | 19.02 ± 2.96a | <0.0001 |
| Smooth muscle fibers Sv (%) | 22.12 ± 1.94 | 10.90 ± 1.35 a | 15.43 ± 2.48 a | 9.90 ± 1.37 a, c | <0.0001 |
| Elastic system fibers Sv (%) | 12.44 ± 2.66 | 19.25 ± 2.08a | 14.25 ± 1.82 | 19.80 ± 2.51 a, c | <0.0001 |
C: Control group; D: Dutasteride group; T: Tamsulosin group; DT: Dutasteride associated with Tamsulosin group; Sv: Surface density.
* p value represents the ANOVA results. Bonferroni’s post test results are signalized by: a when different from C; b when different from D; and c when different from T.
Data expressed as mean ± standard deviation.