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. 2023 Feb 3;77(7):699–704. doi: 10.1038/s41430-023-01258-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Dose-response meta-analysis on the relation of (a) 100% fruit juice with incident type 2 diabetes in adults in 3 prospective cohort comparisons identified by EFSA (b) non-specified fruit juice with incident type 2 diabetes in 4 prospective cohort comparisons identified by EFSA. Individual comparisons are represented by the circles, with the weight of the comparison in the analysis represented by the size of the circle. The solid red line represents the linear dose response assessed by one stage linear mixed effects meta-analysis. The solid black line and outer black dashed lines represent the non-linear dose response and 95% confidence intervals, respectively, which were modelled with restricted cubic splines with 3 knots. Departure from linearity was assessed using the Wald’s test, with significance set at P < 0.05. CI confidence interval, RR relative risk.