Table 1.

Four known TAAD risk loci after discovery in the MVP and independent replication

Chr:pos (hg19)	rsID	EA	NEA	EAF	Overall OR	Overall 95% CI	Overall P	Gene/locus	Annotation
3:41,960,006	rs1716975	T	C	0.321	1.14	1.11–1.18	2.96 × 10−15	ULK4	missense_variant
10:114,773,927	rs7904519	A	G	0.519	1.09	1.06–1.12	5.71 × 10−9	TCF7L2	intron_variant
12:57,527,283	rs11172113	T	C	0.592	1.11	1.08–1.14	6.98 × 10−16	LRP1	intron_variant
15:48,883,939	rs1818275	C	T	0.174	1.35	1.30–1.41	2.54 × 10−47	FBN1	intron_variant

Abbreviations: EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; rsID, reference SNP cluster ID.