Table 2.

Seventeen new TAAD risk loci after discovery in the MVP and independent replication

Chr:pos (hg19)	rsID	EA	NEA	EAF	Overall OR	Overall 95% CI	Overall P	Gene/locus*	Annotation
1:9,436,538	rs4596926	A	G	0.404	1.10	1.07–1.13	3.94 × 10−11	(SPSB1)	regulatory_region_variant
2:164,915,279	rs13002621	G	A	0.222	1.12	1.08–1.15	2.68 × 10−12	AC092684.1	intron_variant
2:19,729,131	rs1863777	T	C	0.361	1.14	1.11–1.17	1.67 × 10−19	(OSR1)	intergenic_variant
2:238,227,919	rs6759927	G	A	0.301	1.11	1.08–1.14	3.57 × 10−12	COL6A3	downstream_gene_variant
4:146,814,640	rs7666150	C	T	0.504	1.13	1.10–1.16	6.58 × 10−17	ZNF827	intron_variant
5:122,441,482	rs337128	C	A	0.513	1.12	1.09–1.15	2.74 × 10−16	PRDM6	intron_variant
5:95,566,562	rs55745974	A	T	0.658	1.20	1.16–1.23	1.54 × 10−32	CTD-2337A12.1	intron_variant
7:35,293,972	rs336284	A	G	0.485	1.1	1.08–1.14	6.23 × 10−13	TBX20	upstream_gene_variant
7:73,431,693	rs62465578	T	G	0.431	1.18	1.15–1.21	2.94 × 10−31	(ELN)	regulatory_region_variant
9:127,883,905	rs139650453	A	G	0.875	1.15	1.10–1.20	4.98 × 10−10	SCAI	intron_variant
10:96,061,793	rs4394764	G	A	0.810	1.15	1.11–1.19	4.52 × 10−17	PLCE1	intron_variant
11:130,271,647	rs747249	G	A	0.619	1.16	1.13–1.19	5.50 × 10−25	ADAMTS8	downstream_gene_variant
13:22,861,921	rs9316871	A	G	0.783	1.21	1.18–1.25	3.03 × 10−32	(AL354828.1)	regulatory_region_variant
13:50,810,171	rs2765768	G	A	0.307	1.10	1.07–1.13	4.85 × 10−11	DLEU1	intron_variant
15:71,612,514	rs1441358	T	G	0.643	1.12	1.09–1.15	4.50 × 10−16	THSD4	intron_variant
16:83,045,790	rs7500448	G	A	0.241	1.13	1.09–1.16	2.47 × 10−13	CDH13	intron_variant
17:2,097,583	rs1002135	G	T	0.398	1.11	1.09–1.14	5.10 × 10−16	SMG6	intron_variant

*Genes for variants that are outside the transcript boundary of a protein-coding gene are shown with the nearest candidate gene in parentheses (for example, (OSR1)).