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. 2023 Jun 29;55(7):1149–1163. doi: 10.1038/s41588-023-01424-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Schematic representation of single-cell CUT&Tag of E10.5 WT and Fam5^snv r4 Isl1⁺ neurons targeting NR2F1. scATAC-seq, single-cell assay for transposase-accessible chromatin with high-throughput sequencing. b, UMAP embedding of NR2F1 single-cell CUT&Tag experiment for two Fam5^SNV/SNV (replicate (Rep) 1 = 2,274 cells, Rep 2 = 2,740 cells) and two WT (Rep 1 = 2,572 cells, Rep 2 = 1,377) age-matched biological replicates. c, Pseudobulk single-cell CUT&Tag profile of NR2F1 around the Gata2 regulatory region shown as individual and combined replicates (WT in blue and Fam5^SNV/SNV in red–yellow). Location of the cREs relative to mouse Gata2 and Dnajb8 is shown. Note the reduction in the height of the cRE2 peaks (vertical pink shading) in the Fam5^SNV/SNV replicates.