Table 2.
Toxicokinetic parameters of difenidol.
| Biological sample | Tmax (h) | Cmax (μg/mL or μg/g) | t1/2k01 (h) | t1/2k10 (h) | t1/2α (h) | t1/2β (h) |
|---|---|---|---|---|---|---|
| Heart | 2.85 | 12.93 | 0.48 | 27.84 | – | – |
| Liver | 3.43 | 33.64 | 0.84 | 11.79 | – | – |
| Spleen | 8.14 | 11.49 | 5.48 | 5.48 | – | – |
| Lung | 2.63 | 47.08 | 0.40 | 6.86 | – | – |
| Kidney | 6.55 | 22.95 | 1.63 | 21.51 | – | – |
| Brain | 3.41 | 12.86 | 0.73 | 16.08 | – | – |
| Stomach | 2.21 | 326.90 | 1.53 | 1.53 | – | – |
| Heart-blood | 1.95 | 4.68 | 0.41 | 9.58 | 0.89 | 20.67 |
Tmax, Time of peak; Cmax, concentration of peak; t1/2k01, absorption half-life; t1/2k10, elimination half-life; t1/2α, half-life of distributed phase; t1/2β, half-life of elimination phase.