Method		High SNR	Low SNR
FDR-generalized Wiener filtering	HiFi-SIM	No defocus information while maintaining sample detail	The quality and resolution of the reconstructed images are degraded by noise
	Open-SIM	Cannot suppress defocus information
	fairSIM	Can suppress defocus information, but has more artifacts
SDR	JSFR-SIM	Can achieve the same resolution as OpenSIM, but the ability to suppress defocus information is not as good as HiFi-SIM	More susceptible to noise, reconstruction results are almost completely submerged in noise
	SP-SIM	Reconstruction results are low contrast and discontinuous
FDR- regularization-based iterative algorithm	TV-SIM	Reduced resolution of reconstructed image due to stair-step artifacts	Reduced resolution of reconstructed image due to stair-step artifacts
	Hessian-SIM	Maintains the resolution of the original OpenSIM output	The quality of the reconstructed images is degraded by noise
	Sparse-SIM	Can further enhance the image resolution and effectively suppress defocus information	There is a trade-off between noise suppression and contrast enhancement
	MRA	Can further enhance the image resolution
	DeepMRA	Can further enhance the image resolution and effectively suppress defocus information