Table 3.

The observational and genetic associations between BMI and life satisfaction in the CKB and UKB stratified by sex and urban and rural regions.

			Observational		Genetic
Study	Strata	Region	Beta (95% CI) per SD higher BMI	Pa	Beta (95% CI) per SD higher BMI	Pb
CKB	All	Both	0.058 (0.053, 0.063)	<1.00E-15	−0.028 (−0.055, −0.002)	0.04
	Male	Both	0.054 (0.047, 0.062)	<1.00E-15	−0.077 (−0.123, −0.030)	1.00E-03
	Female	Both	0.062 (0.056, 0.069)	<1.00E-15	−0.004 (−0.037, 0.028)	0.80
	All	Urban only	0.048 (0.041, 0.055)	<1.00E-15	0.006 (−0.036, 0.048)	0.78
	Male	Urban only	0.059 (0.048, 0.070)	<1.00E-15	−0.033 (−0.109, 0.042)	0.39
	Female	Urban only	0.043 (0.034, 0.052)	<1.00E-15	0.024 (−0.027, 0.075)	0.36
	All	Rural only	0.066 (0.059, 0.072)	<1.00E-15	−0.051 (−0.085, −0.016)	4.00E-03
	Male	Rural only	0.072 (0.062, 0.081)	<1.00E-15	−0.103 (−0.162, −0.044)	1.00E-03
	Female	Rural only	0.063 (0.055, 0.072)	<1.00E-15	−0.023 (−0.066, 0.019)	0.28
UKB	All	Both	−0.019 (−0.023, −0.014)	<1.00E-15	−0.019 (−0.054, 0.016)	0.28
	Male	Both	−0.002 (−0.008, 0.005)	0.65	−0.003 (−0.049, 0.043)	0.90
	Female	Both	−0.029 (−0.035, −0.023)	<1.00E-15	−0.030 (−0.073, 0.014)	0.19
	All	Urban only	−0.020 (−0.025, −0.015)	2.3E-15	−0.027 (−0.066, 0.011)	0.16
	Male	Urban only	−0.005 (−0.013, 0.002)	0.17	−0.003 (−0.054, 0.048)	0.90
	Female	Urban only	−0.028 (−0.035, −0.022)	<1.00E-15	−0.031 (−0.079, 0.016)	0.19
	All	Rural only	−0.013 (−0.024, −0.002)	0.02	0.030 (−0.058, 0.119)	0.50
	Male	Rural only	0.015 (−0.002, 0.032)	0.08	0.026 (−0.085, 0.137)	0.64
	Female	Rural only	−0.030 (−0.045, −0.015)	6.80E-05	0.010 (−0.111, 0.130)	0.88

^aP adjusted for age, region (CKB only), centre (UKB only) and sex.

^bP adjusted for age, region (CKB only), centre (UKB only), sex, and principal components.