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. 2023 Jul 11;14:4124. doi: 10.1038/s41467-023-39813-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Numbers of genes with DCIs in seven cell types of a kidney tumor. b Stratification of genes with DCIs based on the status of gene expression levels and most dominant transcripts (MDTs). dMDT distinct among cell types, sMDT shared across cell types. c Heatmap of the cellular frequencies of top cell-type-specific MDTs. d Violin plot of numbers of exons of tumor and normal cell preferred isoforms. P-value: two-sided paired t-test (n = 335). Boxes inside the violin plots are centered at the median and bounded by the first (Q1) and third quartile (Q3). e Pair-wised scatter plot of the numbers of exons of expressed genes in tumor and normal cells. f Top gene ontologies (MSigDB: GO: BP) of cell-type-specific DCI genes. P-values: Fisher’s Exact t-test, adjusted with Benjamini and Hochberg method. g Examples of cellular frequencies of isoforms of genes expressing different MDTs in different cell types. h Examples of cellular frequencies of isoforms of genes expressing the same MDTs in different cell types. Source data are provided as a Source Data file.